Association between Promoter Polymorphisms of TFF1, TFF2, and TFF3 and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population |
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| Authors: | Eun-Heui Jin Sang-Il Lee JaeWoo Kim Eun Young Seo Su Yel Lee Gang Min Hur Sanghee Shin Jang Hee Hong |
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| Affiliation: | 1Clinical Trials Center, Chungnam National University Hospital, Daejeon, Korea.;2Department of Surgery, Chungnam National University Hospital, Daejeon, Korea.;3Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.;4National Biobank of Korea, Chungnam National University Hospital, Daejeon, Korea.;5Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Korea. |
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| Abstract: | Gastric cancer is one of the most common cancers in the world. The aims of this study were to evaluate the association between polymorphisms in TFF gene family, TFF1, TFF2, and TFF3 and the risk of gastric cancer (GC) and GC subgroups in a Korean population via a case-control study. The eight polymorphisms in TFF gene family were identified by sequencing and genotyped with 377 GC patients and 396 controls by using TaqMan genotyping assay. The rs184432 TT genotype of TFF1 was significantly associated with a reduced risk of GC (odds ratio, [OR) = 0.45; 95% confidence interval, [CI] = 0.25-0.82; P = 0.009), more protective against diffuse-type GC (OR = 0.20; 95% CI = 0.05-0.89; P = 0.035) than GC (OR = 0.34; 95% CI = 0.14-0.82; P = 0.017) in subjects aged < 60 yr, and correlated with lymph node metastasis negative GC and diffuse-type GC (OR = 0.44; 95% CI = 0.23-0.86; P = 0.016 and OR = 0.20; 95% CI = 0.05-0.87; P = 0.031, respectively). In addition, a decreased risk of lymph node metastasis negative GC and diffuse-type GC was observed for rs225359 TT genotype of TFF1 (OR = 0.46, 95% CI = 0.24-0.88; P = 0.020 and OR = 0.21, 95% CI = 0.05-0.88; P = 0.033, respectively). These findings suggest that the rs184432 and rs225359 polymorphisms in TFF1 have protective effects for GC and contribute to the development of GC in Korean individuals.Graphical Abstract | |
| Keywords: | Control-case Studies Diffuse Type Gastric Neoplasms Polymorphism TFF1 Protein Human TFF2 Protein Human TFF3 Protein Human |
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