Triple-Y syndrome following ICSI treatment in a couple with normal chromosomes: case report

We report the case of 48,XYYY in a fetus resulting from ICSI treatment in a chromosomally normal couple. A 35 year old couple underwent an ICSI treatment resulting in a maintained clinical pregnancy. Amniocentesis at 13 weeks identified the Triple-Y syndrome in the fetus. Both the parents had normal karyotypes (46,XX and 46,XY). The pregnancy was terminated at 18 weeks and fetal tissue culture confirmed the 48,XYYY syndrome. This is the first reported case of the Triple-Y syndrome following ICSI treatment in a chromosomally normal couple.