八种抗癫痫药物对小鼠马桑内酯惊厥、电惊厥的作用比较及对学习记忆的影响

用两种惊厥模型,通过跳台法和避暗法观察了临床常用的几种抗癲痫药抗惊厥作用,以及对学习记忆的影响。结果表明:对抗马桑内酯惊厥,以硝基安定和氯硝基安定效果最好,苯巴比妥及丙戊酸钠次之,酰胺咪嗪和芹菜甲素无效,而苯妥英钠及抗痫灵则能加重惊厥;在电惊厥模型中,以苯妥英钠和苯巴比妥效果最佳,丙戊酸钠及酰胺咪嗪次之,其它药物无效;除芹菜甲素外,其余七种药物均能削弱记忆获得。硝基安定和氯硝基安定可保护马桑内酯惊厥对记忆的损害,而硝基安定能加重电惊厥对记忆的损害。

EFFECTS OF EIGHT ANTIEPILEPTIC DRUGS ON CODIARIAE AND ELECTRIC INDUCED CONVULSION AND IMPAIRMENT OF LEARNING AND MEMORY IN MICE

For evaluation of the effect of eight antiepileptic drugs on epileptic seizures, both electric and coriariae-induced epileptic models in mice were used. Effect sof these drugs on learning and memory was also observed using passive avoidance learning-step down and step through tests in mice. Results showed that clonazepam and nitrazepam exhibited the most effective in antagonizing coriariae-induced epileptic seizures, then was pentobarbital and valproate in decreasing order. On the contrary, carbamezepine and Ag-1 deteriorated the coriariae-induced convulsion, While in the electric convulsion model, the effective order was phenytoin, phenobarbital, carbamezepine and valproate. Ag-1, antiepilepsirine, nitrazepam and clonazepam were inactive. All drugs but Ag-1 impaired acquisition of memory in normal mice. Nitrazepam and clonazepam improved impairment of consolidation of memory induced by coriariae. Nitrazepam and phenytoin destroyed the deficit of memory induced by electric convulsion. Other antiepilcptic drugs showed no effect on memory in both epileptic models.