IgG型抗心磷脂抗体与不孕(不育)关系的研究

目的:探讨IgG型抗心磷脂抗体在不孕(育)症中的作用。方法:应用ELISA法检测178对不孕(育)症夫妇血清IgG型抗心磷脂抗体,并以94对同一地区的正常健康生育夫妇为对照。结果:不孕(育)症夫妇IgG型抗心磷脂抗体阳性率为8.43％(30/356),与对照组(3.72％)相比有显著性差异(P<0.05,x~2=4.29,其相对危险比OR=2.38)。其中继发性不孕者IgG型抗心磷脂抗体阳性率13.38％(19/142)高于原发性不孕的5.14％(11/214,P<0.01,x~2=7.51,OR=2.85)和对照组的3.72％(7/188,P<0.01,x~2=10.13,OR=3.90)。原发性不孕者与对照组无差异(P>0.05,x~2=0.47,OR=1.40)。结论:IgG型抗心磷脂抗体与不孕(育)有一定相关性,提示抗心磷脂抗体可能涉及不孕(育)症的致病机制。

Study of the Relationship between IgG Anticardiolipin Antibody and Infertility

Objective: To investigate the role of immunoglobuling G anticardiolipin antibody (IgG AC A) in infertility. Methods: The Serum samples of 178 couples with infertility and 94 couples with normal pregnant history were tested by ELISA. Results;The total positive rate of IgG ACA in serum was 8. 43% (30/356) in infertility group , which was significantly higher than that in controlled group(3. 72% ,7/188) , P < 0. 05, x2 = 4. 29, OR = 2. 38. The positive rate of IgG ACA among second infertile persons was 13. 38% ( 19/ 142) , which was higher than that of original infertile persons 5. 14% (11/214) ,F<0. 01 ,x2 =7. 51,OR =2. 85. It was also higher than that in controlled group,P <0. 01 ,x2 =10. 13,OR = 3. 90. There was no significant difference between original person and controlled group,P >0. 05,x2 =0.47,OR = 1. 40. Conclusion: There is relative relationship between IgG ACA and infertility,whicn means IgG ACA may be one of pathogenisis for infertility.