氯吡格雷联合阿司匹林、溶栓治疗急性ST段抬高型心肌梗死的疗效观察

目的观察常规溶栓联合氯吡格雷治疗对急性ST段抬高型心肌梗死近期心脏事件的影响。方法符合入选条件的患者随机分为常规溶栓治疗组(34例)和氯吡格雷组(36例,在常规溶栓治疗的基础上即刻300mg,随后每日1次75mg,连用7d)。结果7d后氯吡格雷组复合终点(13.90%)与常规治疗组(29.41%)比较差异有统计学意义(P<0.05),而主要的副作用两组之间比较差异无统计学意义(P>0.05)。结论氯吡格雷对急性ST段抬高型心肌梗死患者的近期(7d)心脏事件是安全有效的。

Addition of clopidogrel to aspirin and fibrinolytic therapy for acute myocardial infarction with ST-segment elevation

Objective To observe the effect on addition of clopidogrel to aspirin and fibrinolytic therapy for acute myocardial infarction with ST-segment elevation. Methods Seventy patients with acute myocardial infarction with ST-segment elevation were randomly divided into two groups: general group was 34 cases with routine aspirin and fibrinolytic therapy, clopidogrel group was 36 cases who were given with clopidogrel (300 mg immediately at the first time ,then 75 mg daily , altogether seven days) besides routine aspirin and fibrinolytic therapy. Results The complex end points of seven days later in clopidogrel group were significantly lower than those in general group (13.90% vs 29.41%, P< 0.05 ). Conclusion Clopidogrel is safe and effective for acute myocardial infarction with ST-segment elevation.