| 父源嵌合型t(13;13)导致胚胎染色体不平衡和流产 |
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| 引用本文： | 张爱琴,崔英霞,王咏梅,黄宇烽. 父源嵌合型t(13;13)导致胚胎染色体不平衡和流产[J]. 中国优生与遗传杂志, 2005, 13(4): 52-53 |
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| 作者姓名： | 张爱琴 崔英霞 王咏梅 黄宇烽 |
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| 作者单位： | 南京军区南京总医院生殖遗传研究室,210002 |
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| 摘 要： | 目的报告1例嵌合型的t(13;13)致妻5次流产的男性携带者,并对胚胎流产的原因进行讨论.方法对流产胚胎组织进行15个DNA短串联重复序列分析.结果 t(13;13)携带者的流产胚胎检测D13S317位点和D13S258 位点都仅有1个源自母亲微卫星标志物.未提示有其它染色体不平衡.结论嵌合型的t(13;13)携带者这次胚胎流产原因是由于13号染色体不平衡所致.
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| 关 键 词： | 短串联重复序列 流产胚胎 染色体不平衡 |
| 文章编号： | 1006-9534(2005)04-0052-02 |
| 修稿时间： | 2004-08-12 |
Paternal mosaicism t (13:13) resulted in an embryonic chromosomal imbalance and abortion |
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| ZHANG Aiqin,CUI Ying-xia,WANG Yong-mei,HUANG Yu-feng. Paternal mosaicism t (13:13) resulted in an embryonic chromosomal imbalance and abortion[J]. Chinese Journal of Birth Health & Heredity, 2005, 13(4): 52-53 |
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| Authors: | ZHANG Aiqin CUI Ying-xia WANG Yong-mei HUANG Yu-feng |
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| Abstract: | Objective: We reported in the paper a male carrier of mosaic karytype 45,XY, t(13;13)/46,XY resulted in his wife of five spontaneous abortions and discussed the cause of this pregnancy loss. Methods: 15 short- tandem-repeat (STR) microsatellite marker loci were analyzed to evaluate the parents' genetic contribution to the aborted embryo. Results: Only an allele from the mother was found from the aborted embryonic tissues in locus D13S317 and D13S258. Conclusion: imbalenced chromosome 13 of the embryo is the cause of his abortion. |
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| Keywords: | Short tandem repeats(STR) Aborted fetus Chromosomal imbalance |
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