| HPLC法测定喘得安颗粒中盐酸麻黄碱的含量 |
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| 引用本文： | 张虹,李华林,吴德玲.HPLC法测定喘得安颗粒中盐酸麻黄碱的含量[J].安徽医药,2010,14(4):413-414. |
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| 作者姓名： | 张虹 李华林 吴德玲 |
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| 作者单位： | 安徽省医药科技实业公司,安徽,合肥,230001;安徽中医学院,药学院,安徽,合肥,230031;安徽省现代中药重点实验室,安徽,合肥,230031 |
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| 摘 要： | 目的建立喘得安颗粒中盐酸麻黄碱的含量测定方法。方法采用高效液相色谱法。选择C18色谱柱，甲醇-水-磷酸（23：77：0．3）为流动相；流速1．0ml·min^-1，检测波长为210nm。结果盐酸麻黄碱在0．249—7．470μg范围内呈良好的线性关系，平均回收率为97．50％，RSD=0．86％。结论定量方法准确、可靠、稳定，可用于制剂的质量控制。
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| 关 键 词： | HPLC 喘得安颗粒 盐酸麻黄碱 含量测定 |
Determination of ephedrine hydrochloride in chuandean granules by HPLC |
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| ZHANG Hong,LI Hua-lin,WU De-ling.Determination of ephedrine hydrochloride in chuandean granules by HPLC[J].Anhui Medical and Pharmaceutical Journal,2010,14(4):413-414. |
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| Authors: | ZHANG Hong LI Hua-lin WU De-ling |
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| Institution: | 1.Anhui Pharmaceutical Science & Technology Corporation;Hefei 230001;China;2.School of Pharmaceutical Science;Anhui College of Traditional Chinese Medicine;Hefei 230031;3.Anhui Key Laboratory of Modernized Chinese Material;China |
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| Abstract: | Aim To establish a HPLC method for the determination of ephedrine hydrochloride in chuandean granules.Methods Ephedrine hydrochloride was determined by HPLC.Methanol-water-phosphoric acid(23:77:0.3) solution was used as the mobile phase,the column was C18,the flow rate was 1.0 ml·min-1 and the detection wavelength was at 210 nm.Results For ephedrine hydrochloride,the linear range was from 0.249 to 7.470 μg,and the average recovery was 97.50% with RSD of 0.86%.Conclusion The method is accurate,reliable,stable and can be applied to the quality control of the preparation. |
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| Keywords: | HPLC chuandean granules ephedrine hydrochloride determination |
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