Correlation of enzyme-linked immunosorbent assays for serum human immunodeficiency virus antigen and antibodies to recombinant viral proteins with subsequent clinical outcomes in a cohort of asymptomatic homosexual men |
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| Authors: | K H Mayer L A Falk D A Paul G J Dawson A M Stoddard J McCusker S P Saltzman M W Moon R Ferriani J E Groopman |
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| Affiliation: | 1. Fenway Community Health Center, Boston, Massachusetts, USA;2. Memorial Hospital, Pawtucket, Rhode Island, USA;3. Brown University, Providence, Rhode Island, USA;4. Abbott Laboratories, North Chicago, Illinois, USA;5. Division of Public Health, School of Health Sciences, University of Massachusetts, Amherst, Massachusetts, USA;6. Department of Medicine, New England Deaconess Hospital and Harvard Medical School, Boston, Massachusetts, USA;1. Department of Pharmacy, Hyogo Medical University Hospital, Nishinomiya, Hyogo, Japan;2. Department of Pharmacy, Gifu University Hospital, Gifu, Gifu, Japan;3. Division of Pharmacy, Chiba University Hospital, Chiba, Chiba, Japan;4. Department of Hospital Pharmacy, Sapporo Medical University Hospital, Sapporo, Hokkaido, Japan;5. Department of Pharmacy, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan;6. Department of Pharmacy, Kobe University Hospital, Kobe, Japan;7. Division of Pharmacy, Wakayama Medical University Hospital, Wakayama, Wakayama, Japan;8. Division of Pharmacy, Himeji Medical Center, Himeji, Hyogo, Japan;9. Department of Pharmacy, Nara Medical University Hospital, Kashihara, Nara, Japan;10. Division of Pharmacy, Japanese Red Cross Kyoto Daiichi Hospital, Higashiyama, Kyoto, Japan;11. Department of Pharmaceutical Services, Hiroshima University Hospital, Hiroshima, Hiroshima, Japan;1. Ifakara Health Institute, Ifakara, the United Republic of Tanzania;2. St. Francis Referral Hospital, Ifakara, the United Republic of Tanzania;3. Swiss Tropical & Public Health Institute, Allschwil, Switzerland;4. University of Basel, Basel, Switzerland;1. Dept. of Infectious diseases, Medical Faculty, Trakia University, Stara Zagora, Bulgaria;2. Dept. of Imaging Diagnostic, Medical Faculty, Trakia University, Stara Zagora, Bulgaria;3. Dept. of Ophthalmology, University Hospital “Prof. Stoyan Kirkovitch”, Stara Zagora, Bulgaria;4. Dept. of Neurology, Medical Faculty, Trakia University, Stara Zagora, Bulgaria |
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| Abstract: | A cohort of asymptomatic homosexual men at a Boston community health center was screened for the presence of human immunodeficiency virus (HIV) serum antigen and antibodies to recombinant proteins containing portions of the envelope and the gag (core) gene products. Of 196 asymptomatic men screened, 149 were antigen-negative/antibody-negative, 41 were antigen-negative/antibody-positive, and six were antigen-positive/antibody-positive. All three men in whom the acquired immune deficiency syndrome (AIDS) developed over the next year were antigen-positive at enrollment. Although a larger portion of the men who were antigen-positive and did not demonstrate progression to AIDS after one year had thrush, zoster, or generalized lymphadenopathy, the associations were not statistically significant. Whereas all of the seropositive men had antibody to viral envelope antigens, about a quarter did not have detectable antibodies to recombinant core antigens. However, all of these men had detectable antibody to core antigens by Western blot. Titers to recombinant core and envelope antigens tended to be lower in the men with AIDS. HIV-infected persons who are more likely to have enhanced immuno-compromise may be identified by these newer tests, but further longitudinal studies will be necessary to fully understand their prognostic value. |
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