常压模拟高住低练对大鼠促红细胞生成素及红细胞相关指标的影响

目的 :探讨常压下模拟高住 (相当于海拔 30 0 0m)低练对大鼠促红细胞生成素及红细胞相关指标的影响。方法 :40只雄性SD大鼠随机分为四组 :低住安静组、低住低练组、常压高住安静组和常压高住低练组 ,高住组大鼠每天在模拟 30 0 0m高度休息 1 2h ,运动组大鼠每天在常氧状态下进行速度为 2 5m/min的跑台训练 ,1h/d,5d/w ,测定 4w后大鼠血清EPO、Hb、RBC及HCT变化。结果 :常压高住安静组和常压高住低练组大鼠血清EPO、Hb、RBC及HCT值均显著增加 (P <0 0 1、P<0 0 5) ,为提高机体摄氧水平提供了可能

Effect of Simulated HiLo Training on Serum Erythropoietin and Related Indexes of Erythrocyte in Rats

Objective To study the effect of simulated HiLo training(altitude 3000m) on serum erythropoietin and related indexes of erythrocyte in rats. Method Forty male Sprague-Dawley rats were randomly parted into four groups: sedentary living-low, trained living-low, sedentary living-high, trained living-high. The living-high rats stayed in a room of 14.5% oxygen everyday for 12 hours, and the trained rats ran on a treadmill at speed of 25m/min for 1hr/day, 5days/week. After four weeks,the serum erythropoietin(EPO),hemoglobin(Hb),red blood cell (RBC)and haematocrit(HCT)were determined.Result The serum EPO, Hb, HCT, the number of RBC in sedentary living-high group were significantly higher than those in sedentary living-low group respectively,and the same reults were to trained living-high group,compared with trained living-low.Conclusion The intermittent hypoxia could increase the levels of EPO, Hb, RBC and HCT,which made it possible for the blood to transport more oxygen to the body.