干细胞移植治疗糖尿病的国内外研究趋势分析

背景：糖尿病是一种特异性针对胰岛β细胞的自身免疫性疾病,可以通过胰腺移植或胰岛移植达到治疗效果,由于供体困难和排斥反应限制了临床应用。目的：对干细胞移植治疗糖尿病研究文献的发展趋势进行多层次探讨分析。方法：对中国CNKI数据库学术期刊和Web of Science数据库2002/2011收录有关干细胞移植治疗糖尿病研究的文献进行分析,运用数据库的分析功能和Excel软件图表的功能分析数据特征。并对CNKI数据库收录不同干细胞移植治疗糖尿病研究的文献进行分析。结果与结论：CNKI数据库学术期刊2002/2011共收录128篇与干细胞移植治疗糖尿病研究相关的文献,Web of Science数据库共收录725篇相关文献,文献数量均处于逐年上升的趋势。CNKI数据库收录的文献主要以骨髓间充质干细胞、胰腺干细胞和造血干细胞的研究最多。文献的学科类别均以内分泌代谢分类为主。Web of Science数据库收录发文量较多的来源期刊和相关机构的文献数量均多于CNKI数据库,发文量较多的国家是美国。中国的国家自然科学基金在干细胞移植治疗糖尿病研究领域做出重要贡献。

Stem cells transplantation in the treatment of diabetes

BACKGROUND： Diabetes is a specific autoimmune disease for pancreatic β cell; it can be treated by pancreas transplantation or islet transplantation, but due to the donor and the rejection, the clinical application is limited. OBJECTIVE： To multi-level explore the development trends of the researches on stem cells transplantation for the treatment of diabetes. METHODS： The articles on stem cells transplantation for the treatment of diabetes were selected in the CNKI database and Web of Science database from 2002 to 2011, and the analysis capabilities of the database and Excel software chart function were used to analyze the data characteristics. The articles on the stem cells transplantation for the treatment of diabetes in the CNKI database were analyzed. RESULTS AND CONCLUSION： A total of 128 articles on stem cells transplantation for the treatment of diabetes were selected from the CNKI database, and 725 articles were searched from the Web of Science database, and the number of the articles was in the increasing trend. The articles in the CNKI database are mainly about the bone marrow mesenchymal stern cells, pancreatic stem cells and hematopoietic stem cells. The categories of the articles are mainly the endocrine metabolic classification. The number of the articles in the Web of Science database is larger than that in the CNKI database, and most of the articles were published by US. The National Natural Science Foundation of China plays an important role in the research on stem cells transplantation for the treatment of diabetes.