含锌羟基磷灰石二氧化钛复合涂层的抗菌性能

背景：提高钛种植体的抗菌性能,降低种植体周围炎的发生,是提高钛种植体成功率的有效方法。目的：观察含锌羟基磷灰石二氧化钛复合涂层的抗菌性能。方法：在纯钛表面先通过微弧氧化方法形成多孔二氧化钛,然后通过溶胶-凝胶法在其上形成含锌羟基磷灰石二氧化钛生物涂层。采用电感耦合等离子发射光谱仪测定各组钛样品Zn2＋的释放浓度;通过抑菌实验及扫描电镜观察接种于复合涂层钛样品表面的牙龈卟啉单胞菌黏附数量和形态。结果与结论：在Tris缓冲液中Zn2＋的释放浓度随着前体溶液中Zn/Ca摩尔比的增加而增加,牙龈卟啉单胞菌在复合涂层钛样品表面生长受到明显的抑制,黏附在材料表面的细菌形态发生改变。结果可见含锌羟基磷灰石二氧化钛复合涂层具有较好的抑菌性能。

Antibacterial property of a zinc-containing hydroxyapatite/titania hybrid coating

BACKGROUND：The effective ways to improve the success rate of titanium implants are to improve the antibacterial properties of titanium implants and reduce the incidence of peri-implantitis.OBJECTIVE：To investigate the antibacterial properties of the zinc-containing hydroxyapatite （ZnHA）/titania （TiO2） hybrid coating.METHODS：First,a porous titania coating was produced on pure titanium （Ti） by micro-arc oxidation treatment.And then a ZnHA /TiO2 biological coating was prepared via sol-gel method.The concentration of Zn2＋ release of Ti samples in each group was measured by inductively coupled plasma emission spectrometer.The adhesion number and morphologies of Porphyromonas gingivalis W83 implanted on the surface of hybrid coating were characterized by scanning electron microscope and bacteriostasis experiment.RESULTS AND CONCLUSION：The concentration of Zn2＋ release in the Tris buffer was increased with the Zn/Ca molar ratio in precursor solution increased.The growth of Porphyromonas gingivalis on the surface of ZnHA/TiO2 coating was inhibited obviously,and the form of Porphyromonas gingivalis adhered on the surface of coating had changed.These findings suggest that the ZnHA/TiO2 hybrid coatings on titanium implants have good antibacterial property.