|
|||||
|
|
| 中国中部疟疾流行区间日疟原虫对氯喹敏感性的体外检测 | |
| 引用本文： | 陆凤,高琪,夏惠,陶志勇,曹俊,顾亚萍,周华云,金小林. 中国中部疟疾流行区间日疟原虫对氯喹敏感性的体外检测[J]. 中国血吸虫病防治杂志, 2006, 18(4): 265-267 |
| 作者姓名： | 陆凤 高琪 夏惠 陶志勇 曹俊 顾亚萍 周华云 金小林 |
| 作者单位： | 1. 江苏省寄生虫病防治研究所、江苏省寄生虫分子生物学重点实验室、江苏省寄生虫病学重点学科,无锡,214064 2. 蚌埠医学院 3. Mahidol University, Thailand 4. Armed Forces Research Institute of Medical Sciences, Thailand |
| 摘 要： | 目的检测我国间日疟原虫对氯喹的敏感性。方法采用新建立的间日疟原虫药物敏感性体外微量测定技术,对中国中部间日疟流行区门诊确诊的间日疟病例进行药物敏感性测定。结果在完成药物测定的24例间日疟病例中,间日疟原虫对氯喹的IC50几何均数为63.23nmol/L,95%可信区间为26.23~152.40nmol/L,其中至少有6例显示对氯喹产生了抗性。结论在中国中部间日疟流行地区可能已出现间日疟原虫抗氯喹株。 |
| 关 键 词： | 间日疟原虫 氯喹 药物敏感性 |
| 文章编号： | 1005-6661(2006)04-0265-03 |
| 收稿时间： | 2006-06-20 |
| 修稿时间： | 2006-06-20 |
In vitro sensitivity test of Plasmodium vivax to chloroquine in center part of China |
|
| Lu Feng,Gao Qi,Xia Hui,Tao Zhiyong,Cao Jun,Gu Yaping,Zhou Huayun,Jin Xiaolin,Rachanee Udomsangpetch,Jetsumon Sattabongkot. In vitro sensitivity test of Plasmodium vivax to chloroquine in center part of China[J]. Chinese journal of schistosomiasis control, 2006, 18(4): 265-267 | |
| Authors: | Lu Feng Gao Qi Xia Hui Tao Zhiyong Cao Jun Gu Yaping Zhou Huayun Jin Xiaolin Rachanee Udomsangpetch Jetsumon Sattabongkot |
| Affiliation: | 1. Jiangsu Institute of Parasitic Diseases, Jiangsu Provincial Key Lab on Molecular Biology of Parasites, Jiangsu Provincial Key Subject on Parasitic Diseases, Wuxi 214064, China ; 2. Bengbu Medical College ,China; 3. Mahidol University, Thailand ; 4. Armed Forces Research Institute of Medical Sciences, Thailand |
| Abstract: | Objective To test chloroquine sensitivity of Plasmodium vivax.Methods The blood samples were collected from the clinical vivax malaria patients in the center part of China, and a new established in vitro micro-test technique was used to test chloroquine sensitivity of P.vivax. Results Twenty-four samples were successfully tested and the geometric mean IC_ 50 of chloroquine was 63.23 nmol/L and the 95% confidence interval was from 26.23 nmol/L to 152.40 nmol/L. At least 6 isolates showed resistance to chloroquine. Conclusion There may be chloroquine-resistance P.vivax isolates in the center part of China. |
| Keywords: | Plasmodium vivax Chloroquine Drug sensitivity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |