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No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts |
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| Authors: | Barral Sandra Fernández-Cadenas Israel Bis Joshua C Montaner Joan Ikram Arfan M Launer Lenore J Fornage Myriam Schmidt Helena Brickman Adam M Seshadri Sudha Mayeux Richard |
| Institution: | a The Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA b Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA c Neurovascular Research Laboratory Institut de Recerca, Vall d'Hebron Hospital, Universitat Autonoma de Barcelona, Paseo Vall d'Hebron 119-129, 08035, Barcelona, Spain d Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA e Department of Medicine, University of Washington, Seattle, WA, USA f Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands g Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands h Netherlands Consortium for Healthy Aging, The Netherlands i Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD, USA j Brown Foundation Institute of Molecular Medicine, Division of Epidemiology School of Public Health, University of Texas Health Science Center at Houston, TX, USA k Human Genetics Center, Division of Epidemiology School of Public Health, University of Texas Health Science Center at Houston, TX, USA l Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria m Department of Neurology, Columbia University Medical Center, New York, NY, USA n Department of Neurology, Boston University School of Medicine, Boston, MA, USA |
| Abstract: | The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene has been associated with stroke. The majority of the reported ALOX5AP associations have considered non-radiologically confirmed infarcts as the stroke phenotype. We assessed the association of genetic variants in ALOX5AP with stroke defined by the presence of infarcts on brain magnetic resonance imaging (MRI). We studied 202 persons with MRI-defined brain infarcts and 487 healthy individuals of Caribbean Hispanic ancestry. Another sample of European ancestry comprised 1823 persons with MRI-defined brain infarct and 7578 control subjects. Subjects were genotyped for the 4 single nucleotide polymorphisms (SNPs) that define ALOX5AP HapA haplotype. No association was found between SNPs and MRI-defined brain infarcts. Our data do not support the hypothesis that variants in ALOX5AP are associated with risk of MRI-defined brain infarcts. |
| Keywords: | MRI-defined brain infarcts ALOX5AP |
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