|
|||||
|
|
Age-related effects on cortical thickness patterns of the Rhesus monkey brain |
|
| Authors: | Bang-Bon Koo Steven P. SchettlerDonna E. Murray Jong-Min LeeRonald J. Killiany Douglas L. Rosene Dae-Shik Kim Itamar Ronen |
| Affiliation: | a Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA b Center for Biomedical Imaging, Boston University School of Medicine, Boston, MA, USA c Department of Biomedical Engineering, Hanyang University, Seoul, South Korea d Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea e Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA f Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands |
| Abstract: | The Rhesus monkey is a useful model for examining age-related as well as other neurological and developmental effects on the brain, because of the extensive neuroanatomical homology to the human brain, the reduced occurrence of neurological diseases such as Alzheimer's disease, and the possibility of obtaining relevant behavioral data and post-mortem tissue for histological analyses. In this study, cortical thickness measurements based on a cortical surface modeling technique were applied for the first time to investigate cortical thickness patterns in the rhesus monkey brain, and were used to evaluate regional age related effects across a wide range of ages. Age related effects were observed in several cortical areas, in particular in the somato-sensory and motor cortices, where a robust negative correlation of cortical thickness with age was observed, similar to that found in humans. In contrast, results for monkeys compared with humans show significant interspecies differences in cortical thickness patterns in the frontal and the inferior temporal regions. |
| Keywords: | Aging brain Rhesus monkey Gray matter Cerebral cortex Cortical surface modeling Cortical thickness |
| 本文献已被 ScienceDirect 等数据库收录！ | |