前胡丙素对肾性高血压左室肥厚大鼠心功能、左室顺应性及心肌胶原含量的影响

观察前胡丙素对肾性高血压左室肥厚(LVH)大鼠心功能、左室顺应性及心肌胶原含量的影响。用两肾一夹肾性高血压动物模型,ig前胡丙素(Pra-C)9周。结果,与LVH组相比,Pra-C组的CF/HWW及CO/HWW分别增加31.3%和28.9%;LVSP和-dp/dt_max负值分别增加16.7%和27.8%;LVEDP和T值分别降低34.9%和36.5%;P-V曲线接近正常组水平;左室肌羟脯氨酸降低23.8%。提示Pra-C可提高LVH大鼠心脏收缩及舒张功能,改善心肌顺应性。

EFFECTS OF PRAERUPTORIN C ON CARDIAC DYSFUNCTION,MYOCARDIAL COMPLIANCE AND COLLAGEN CONTENT IN RENOVASCULAR HYPERTENSIVE RATS

The effects of praeruptorin C (Pra-C) on cardiac dysfunction, myocardial compliance, and collagen content in renovascular hypertensive rats have been studied. In rats with left ventricular hypertrophy (LVH), the ratio of cardiac flow (CF)/heart wet weight (HWW) and cardiac output (CO)/HWW decreased by 20.1% and 35.5%; LVSP and -dp/dtmax decreased by 19.4% and 42.1%, while LVEDP and T value were increased by 186.4% and 226%. The left ventricular diastolic pressure-volume (P-V) curve was shifted to the left and down ward compared with that of sham-operated rats. The hydroxyproline content was 5.93 +/- 0.82 mg.g-1 dry weight in the left ventricular myocardial tissue of rats with LVH which was higher than that of sham-operated rats(e.g. 4.01 +/- 0.47 mg.g-1). The content did not change in the right ventricular myocardium. After treated with Pra-C for nine weeks, the CF/HWW and CO/HWW increased by 31.3% and 25.1%, the LVSP and -dp/dtmax increased by 16.7% and 27.8%. The LVEDP and T value was reduced by 34.9% and 36.5%, respectively, compared with those of LVH. The P-V curves of these rats were shifted to the right and in the up-ward direction. The hydroxyproline content was 4.52 +/- 0.3 mg.g-1 dry weight in the left ventricular tissue. These results indicate that Pra-C improved the cardiac contractility and relaxation by increasing the coronary flow and cardiac output, and decreasing the collagen content in the ventricular myocardium.