| 白藜芦醇及其类似物的合成及抗TPA促癌作用研究 |
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| 引用本文： | 陈国良,单韦,徐颖,董金华,张宝凤,计志忠. 白藜芦醇及其类似物的合成及抗TPA促癌作用研究[J]. 沈阳药科大学学报, 2004, 21(4): 261-263 |
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| 作者姓名： | 陈国良 单韦 徐颖 董金华 张宝凤 计志忠 |
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| 作者单位： | 1. 沈阳药科大学制药工程学院,辽宁,沈阳,110016
2. 沈阳药科大学药学院,辽宁,沈阳,110016 |
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| 基金项目： | 国家自然科学基金青年基金资助项目 (3980 0 185 ) |
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| 摘 要： | 目的设计合成白藜芦醇类似物 ,并测试其抗佛波酯 (TPA)促癌作用。方法以 3,5 二羟基苯甲酸为原料经多步反应合成目标化合物 ,采用TPA致小鼠耳肿胀促癌法确定目标化合物抗TPA促癌作用。结果所有合成的目标化合物通过1H NMR确认其结构 ,大部分化合物具有明显的抗TPA促癌作用。结论白藜芦醇及其类似物具有较强抗TPA促癌作用。
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| 关 键 词： | 制备 化学合成 白藜芦醇类似物 抗促癌 TPA |
| 文章编号： | 1006-2858(2004)04-0261-03 |
| 修稿时间： | 2003-11-28 |
Studies on the synthesis of resveratrol and its analogs and their antipromotion of TPA |
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| CHEN Guo-liang,SHAN Wei,XU Ying,DONG Jin-hua,ZHANG Bao-feng,JI Zhi-zhong. Studies on the synthesis of resveratrol and its analogs and their antipromotion of TPA[J]. Journal of Shenyang Pharmaceutical University, 2004, 21(4): 261-263 |
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| Authors: | CHEN Guo-liang SHAN Wei XU Ying DONG Jin-hua ZHANG Bao-feng JI Zhi-zhong |
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| Affiliation: | CHEN Guo-liang1,SHAN Wei1,XU Ying2,DONG Jin-hua1,ZHANG Bao-feng2,JI Zhi-zhong1 |
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| Abstract: | Objective To design and synthesize resveratrol and its analogs,and to assay their activity of preventing the cancer induced by TPA.Methods The target compounds were synthesized from 3,5-dihydroxybenzoic acid.The activity of preventing the cancer induced by TPA was tested.Result The structures of all the target compounds synthesized were confirmed by 1H-NMR.Most target compounds had potent activity of preventing the cancer induced by TPA.Conclusions Resveratrol and its analogs show good antipromotion activity of TPA. |
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| Keywords: | preparation chemical synthesis resveratrol analogs antipromotion TPA |
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