静脉药瘾者血源性病毒感染调查分析

目的　调查静脉药瘾者主要血源传播病毒HBV、HCV、HGV、巨细胞病毒 (CMV)和单纯疱疹病毒 (HSV)的感染率。方法　采用酶联免疫吸附法、放射免疫法、RT -PCR和荧光定量PCR法 ,检测 40 6例静脉药瘾者血清 ,其中共用注射器者 49 0 1% ,同时设立 10 2例正常健康体检者作为对照。结果　静脉药瘾者HBV、HCV、HGV、CMV和HSV的感染率分别是 3 6 45% ,69 7% ,1 97% ,2 71%和 3 45% ,其中总感染人数 3 2 1人 (79 0 6% )和重叠感染人数12 8人 (3 1 53 % ) ,有共用注射器者单项感染率及重叠感染率均高于未共用者 ,2者有显著性差异 (P <0 0 5)。对照组检测仅发现存在HBV感染 (17 6% ) ,其余病毒感染指标均为阴性。结论　静脉药瘾者血源传播病毒感染率明显增高 ,其中以HCV感染最为突出 ,并且共用注射器是导致感染危险增大的要素

Analysis on infection rates of blood transmission virus in intravenous drug users

ObjectiveIn order to assess the infection condition of H BV,HCV,HGV,HSV and CMY in Intravenous Drug Users (IVDUs).MethodsIt is detected that anti-HBV,HCY,HGV,HSV,CMY mark ers by ELISA in 406 sera and 102 normal controls.While we detected HCV RNA by RT -PCR and Fluorescence Quantitative PCR methods. ResultsAnti-HGV,HSV and CMV posi tive is 1.97%,2.71% and 3.45% respctively,total HBV infection rate is 36.45%,HBs Ag carrier 5.91%,HBeAg positive 3.96% in IVDUs.HBV infection rate is 17.65%,HBs Ag carrier 0 98%, HBeAg positive 1.96% in the controls.Others are negative.The infection rates and coinfection rates are very prominent in the injector co-use rs of IVDUs (49.01%). ConclusionIt indicates that IVDUs is high risk populati on of blood transmission virus infection,especially HCV infection.