兔激素性早期股骨头缺血坏死CT灌注成像

目的 分析激素性股骨头缺血坏死(SANFH)模型不同时期的股骨头CT灌注成像(CTPI)及病理改变。 方法 对30只健康日本大耳白兔,以相同方法制成激素性股骨头缺血坏死模型,分别于给药后2、4、6、8及10周行双髋CTPI,绘出股骨头的时间-密度曲线,分析不同阶段股骨头血流量(BF)、血容量(BV)及对比剂平均通过时间(MTT)。完成检查后处死动物取材,光镜下观察不同给药时间股骨头内空骨陷窝数及微血管数。 结果 在给药后2周、4周,BF、BV开始下降;6周、8周,BF、BV明显下降,10周,BF、BV不降反升。MTT在各时间段变化不明显。股骨头内空骨陷窝数及微血管数出现先下降后上升表现。 结论 CTPI能够较全面反映早期激素性SANFH的血供变化。

CT perfusion imaging on steroid-induced avascular necrosis of the femoral head of rabbits

Objective To observe CT perfusion imaging (CTPI) and pathological changes of steroid-induced avascular necrosis of the femoral head (SANFH) in different stages. Methods Thirty Japanese white rabbits were examined with CTPI in the same method in the 2nd, 4th, 6th, 8th and 10th week after injection of Hydrocortisone. Time-density curves (T-DC) was depicted and blood flow (BF), blood volume (BV), mean transit time (MTT) of femoral head in different stage of ischemia were analyzed. After examination, the rabbits were killed, the samples were examined histologically, and the number of empty lacuna and capillary vessels were analyzed. Results BF and BV of femoral head decreased during earlier period (2nd and 4th week), obviously with prolongation of injection (6th and 8th week), but BF and BV increased in the 10th week. MTT did not change obviously. The number of empty lacuna and capillary vessel decreased while earlier period increased. Conclusion CTPI can reflect the blood changes of early stage SANFH.