Giant collagen plaques in Creutzfeld-Jakob disease

Summary We report two cases of Creutzfeld-Jakob disease with clusters of giant collagen fibers. To our knowledge, these abnormally large collagen fibers have never been described in patients with degenerative diseases of the central nervous system. The significance of the formation of such plaque-like large collagen fibers has as yet not been elucidated. It is felt that these represent a product of the degenerative process.Presented in part at the 68th Annual Meeting of the American Association of Neuropathologists, St. Louis, Missouri, June 18–21, 1992