| 系统性红斑狼疮患者HLA—DRB1,DQB1易感基因的研究 |
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| 引用本文： | 金晔,李哲先.系统性红斑狼疮患者HLA—DRB1,DQB1易感基因的研究[J].中华皮肤科杂志,1998,3(1):12-13. |
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| 作者姓名： | 金晔 李哲先 |
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| 作者单位： | 北京友谊医院检验科(金晔!100050，李哲先!100050)，北京红十字血液中心白细胞室(张志欣，李伟，单小燕，袁庆珍，志宏) |
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| 摘 要： | 目的 探索 HL A-DRB1、DQ B1等位基因多态性与系统性红斑狼疮 (SL E)的易感性关系。方法 用聚合酶链反应 -序列特异性引物 (PCR-SSP)方法 ,对 10 4例健康人和 32例 SL E患者的 HL A -DRB1、DRB3、DRB4、DQB1等位基因进行研究。结果和结论 SL E患者中基因频率升高的有 HL A-DRB1* 15 (P<0 .0 5 ,RR=2 .3) ,H L A-DRB1* 16 (P<0 .0 5 ,RR=4.86 ) ,而 DRB1* 0 4明显低于对照组 ;未发现DQB1* 0 4等位基因。
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| 关 键 词： | 红斑狼疮 系统性 HLA-DRB1 DQB1 聚合酶链反应-序列特异性引物 |
Study on HL A-DRB1,DQB1Allele Susceptibility to System ic L upus Erythem atosus |
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| Jin Ye,L i Zhexian,Zhang Zhix in,et al..Study on HL A-DRB1,DQB1Allele Susceptibility to System ic L upus Erythem atosus[J].Chinese Journal of Dermatology,1998,3(1):12-13. |
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| Authors: | Jin Ye L i Zhexian Zhang Zhix in |
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| Institution: | Jin Ye,L i Zhexian,Zhang Zhix in,et al.Dep artment of Clinical L aboratory,Beijing F riendship H ospital,Beijing10 0 0 5 0 |
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| Abstract: | Objective To explore the allelic polymorphism of HL A -DRB1,DQB1loci and suscepti- bility to system ic lupus erythem atosus(SL E) . Methods Polym erase chain reaction-sequence specific prim ers(PCR-SSP) were used to study HL A-DRB1,DRB3,DRB4and DQ B1,alleles in32 patients with SL E and 10 4healthy controls. Results and Conclusion The results showed that the frequencies of DRB1 * 15 (P<0 .0 5 ,RR=2 .3) and DRB1* 16 (P<0 .0 5 ,RR=4.86 ) were significanly higher in SL E patients than those of controls,and DRB1* 0 4allele significantly low er (P <0 .0 5 ,RR=0 .30 3) w hich indicates that it m ight be a protective allele.DQB1* 0 4allele was not found,in this study. |
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| Keywords: | L upus erythem atosus systemic HL A -DQ B1 DRB1 PCR-SSP |
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