| 肝细胞癌生物学行为的研究 |
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| 引用本文： | 赵跃武,孔令非,党伟一,银平章,郝远瑞,刘正国,唐华. 肝细胞癌生物学行为的研究[J]. 河南医学研究, 2002, 11(1): 16-18 |
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| 作者姓名： | 赵跃武 孔令非 党伟一 银平章 郝远瑞 刘正国 唐华 |
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| 作者单位： | 河南省人民医院病理科,河南郑州,450003 |
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| 摘 要： | 目的 :探讨p5 3、nm2 3 -H1、CD44v6、P gp、Fas、FasL和MMPs基因表达与肝细胞癌 (HCC)生物学行为的关系。方法 :用酶谱分析和免疫组化技术对HCC组织中p5 3、nm2 3 -H1、CD44v6、P gp、Fas、FasL和MMPs基因表达水平进行了检测。结果 :HCC组织中p5 3、nm2 3 -H1、CD44v6、P gp、Fas、FasL和MMPs基因表达水平与正常组织相比 ,存在显著性差异 ;同时 ,转移组与无转移组也存在显著性差异。结论 :结果提示p5 3、nm2 3 -H1、CD44v6、P gp、Fas、FasL和MMPs基因表达水平与HCC的生物学行为有关
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| 关 键 词： | 肝细胞癌 基因表达 酶谱 免疫组化 生物学行为 |
| 文章编号： | 1004-437X(2002)01-0016-03 |
| 修稿时间： | 2002-01-28 |
Study on the biological behaviors of hepatocellular carcinoma |
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| ZHAO Yue wu,KONG Ling fei,DANG Wei yi,et al. Study on the biological behaviors of hepatocellular carcinoma[J]. Henan Medical Research, 2002, 11(1): 16-18 |
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| Authors: | ZHAO Yue wu KONG Ling fei DANG Wei yi et al |
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| Abstract: | Objective: To investigate the relationship betwween gene expression of p53,nm23-H1,CD44v6,P gp,Fas,FasL, MMPs and the biological behaviors of hepatocellular carcinoma(HCC).Methods: The level of gene expression of p53,nm23-H1,CD44v6,P gp,Fas,FasL and MMPs from HCC were measured by using zymography and immmunohistochemistry.Results: The level of gene expression of p53,nm23-H1,CD44v6,P gp,Fas,FasL and MMPs from HCC were apparently different than those of normal tissues;meanwhile,with metastasis markly different non-metastasis.Conclusion: The abnormal expression of p53,nm23-H1,CD44v6,P gp,Fas,FasL and MMPs may play the important roles in development and prognosis of HCC. |
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| Keywords: | Hepatocellular Carcinoma Gene expression Zymography immmunohistochemistry Biological Behaviors |
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