对叶百部化学成分研究

目的研究百部科百部属对叶百部Stemonatuberosa的化学成分。方法采用反相C18、硅胶、凝胶柱色谱、制备型HPLC等方法进行分离纯化,通过理化性质、光谱数据结合参考文献鉴定化合物结构。结果从对叶百部根部甲醇提取物中分离鉴定10个化合物,分别鉴定为6-甲氧基-3-甲基-2H-吡喃-2-酮(1)、stilbostemin A(2)、stilbostemin K(3)、stilbostemin P(4)、stilbostemin Q(5)、stilbostemin R(6)、stilbostemin T(7)、stilbostemin W(8)、stilbostemin X(9)、stilbostemin Y(10)。结论化合物1为新的吡喃酮,命名为对叶百部吡喃酮A,化合物2、3为首次从该植物中分离得到。

Chemical constituents of Stemona tuberosa

Objective To study the chemical constituents of Stemona tuberosa. Methods The chemical constituents were isolated and purified by chromatography with RP-C₁₈, silica gel, Sephadex LH-20 and semi-preparative HPLC, and their structures were identified by analysis of spectroscopic data and physicochemical properties as well as relevant references. Results Ten compounds were isolated from the roots of S. tuberosa, and they were elucidated as 6-methoxy-3-methyl-2H-pyran-2-one (1), stilbostemin A (2), stilbostemin K (3), stilbostemin P (4), stilbostemin Q (5), stilbostemin R (6), stilbostemin T (7), stilbostemin W (8), stilbostemin X (9) and stilbostemin Y (10). Conclusion Compound 1 is the new pyrone derivative named as stemonapyrone A. Compounds 2 and 3 are isolated from the plant of S. tuberosa for the first time.