胞外肌动蛋白检测的临床应用

肌动蛋白是细胞骨架微丝系统的主要组成成分,在细胞膜完整性受损的情况下,肌动蛋白被释放到细胞外成为危险相关分子模式的一员。目前已发现的胞外肌动蛋白有三种存在形式:与细胞膜外表面连接、存在于细胞外基质或是游离于循环体液中。胞外肌动蛋白参与多种疾病病理生理过程,作为一种自身抗原也参与许多自身免疫性疾病的发生发展。循环游离肌动蛋白、抗肌动蛋白免疫球蛋白以及肌动蛋白清除系统相关组分均可以作为生物标志物,用于多种疾病的预后判断。

Clinical application of extracellular actin detection

Actin is the main components of actin cytoskeleton wemicrofilament system,in the case of damage to integrity of cell membrane,actin was released into the extracellular,becoming danger-associated molecular patterns(DAMPs).There are three forms of extracellular actin that have been found:the outer surface of the cell membrane,the extracellular matrix,or in the circulatory system.Extracellular actin participates in a variety of pathological processes,involved in the development of many autoimmune diseases as an autoantigen.The level of circulating free actin,anti-actin immunoglobulin and actin clearing system related components can be a biomarker for the prognosis judgement of a variety of diseases.