| 抗角蛋白自身抗体对豚鼠银屑病样皮炎的影响 |
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| 引用本文： | 孙林潮,刘玉峰,刘彦仿,张泰山. 抗角蛋白自身抗体对豚鼠银屑病样皮炎的影响[J]. 医学争鸣, 2002, 23(2): 114-117 |
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| 作者姓名： | 孙林潮 刘玉峰 刘彦仿 张泰山 |
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| 作者单位： | 1. 第四军医大学西京医院全军皮肤性病中心,陕西,西安,710033
2. 第四军医大学基础部理学教研室,陕西,西安,710033 |
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| 基金项目： | “10 35”工程 (国家新药研究与产业化开发项目 )资助课题( 96 -90 1-0 1-38) |
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| 摘 要： | 目的 观察豚鼠抗角蛋白自身抗体（anti-keratin au-toantibody,AK auto Ab）滴度的消长对豚鼠银屑病样皮炎转归的作用。方法 应用心得安乳剂涂抹豚鼠耳廓造成银屑病样皮炎，采用腹腔注射纯化的豚鼠AK auto Ab（高滴度组）、皮下植入自身皮片消耗AK auto Ab（低滴度组）以及不作处理（正常滴度组）作为对照，根据组织病理变化评价豚鼠血清AK auto Ab滴度消长对皮炎转归的影响。结果 AK atuo Ab高滴度组银屑病样皮炎的恢复速度明显于对照组，而低滴度组皮炎恢复最缓慢。结论 AK auto Ab具有促进豚鼠银屑病样皮炎恢复的作用。
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| 关 键 词： | 角蛋白 自身抗体 银屑病 滴度 动物模型 |
| 文章编号： | 1000-2790(2002)02-0114-04 |
| 修稿时间： | 2001-10-23 |
Effect of AK auto Ab on psoriasiform dermatitis of guinea-pig |
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| SUN Lin Chao ,LIU Yu Feng ,LIU Yan Fang ,ZHANG Tai Shan Center of Dermatology , Venereology of Chinese PLA,Xijing Hospital. Effect of AK auto Ab on psoriasiform dermatitis of guinea-pig[J]. Negative, 2002, 23(2): 114-117 |
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| Authors: | SUN Lin Chao LIU Yu Feng LIU Yan Fang ZHANG Tai Shan Center of Dermatology & Venereology of Chinese PLA Xijing Hospital |
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| Affiliation: | SUN Lin Chao 1,LIU Yu Feng 1,LIU Yan Fang 2,ZHANG Tai Shan 1 1Center of Dermatology & Venereology of Chinese PLA,Xijing Hospital,2Department of Pathology,Faculty of Preclinical Medicine,Fourth Military Medical University,Xi'an |
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| Abstract: | AIM To investigate the effect of different titers of AK auto Ab in sera on psoriasiform dermatitis of guinea pig . METHODS Psoriasiform dermatitis was developed in the skin of pinna of guinea pig applied with propranolol. Effects of different AK auto Ab titers in sera on the rehabilitation of psoriasiform dermatitis were observed by means of histological score. RESULTS Injection of AK auto Ab purified from sera of guinea pig promoted rehabilitation of the dermatitis. On the contrary, the decrease of the AK auto Ab titers in sera by transplantation of auto skin into subcutaneous delayed the recovery of dermatitis. CONCLUSION AK auto Ab can improve the recovery of psoriasiform dermatitis of guinea pig. |
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| Keywords: | keratin autoantibodies psoriasis disease models animal |
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