2005年临床分离病原菌的分布及耐药性分析

目的:调查我院临床分离病原菌的分布及耐药状况,为临床用药提供依据。方法:对我院2005年1～12月分离的病原菌作回顾性分析。结果:共检出1572株致病菌,其中革兰阳性菌599株,占38.1%,革兰阴性菌478株,占30.4%,真菌494株,占31.4%。药敏结果:敏感率最高的前三位抗菌素是:万古霉素95.8%、亚胺培南88.2%、头孢吡肟83.6%,而耐药率最高的分别为:克拉霉素79.3%、克林霉素74.0%、红霉素73.5%。结论:临床真菌感染逐年上升;检出革兰阳性菌比例较高且耐药率高;酶抑制剂能明显降低革兰阴性菌的耐药率,但不能明显降低革兰阳性菌的耐药率。应加强抗菌素的临床合理使用。

Analysis of distribution and resistance of pathogen isolated from clinical specimens in 2005

Objective:To investigate the actualities of the distribution and resistance of pathogen isolated from clinical specimens, to provide the basis for clinical rational use drug.Methods:The pathogenes isolated from clinical specimens in 2005 were analysed.Re- sults:It was 1572 pathogenes isolated from clinical specimens which were sent to be examined.Gram positive bacteria was 599,38.1 percent;Gram negative bacteria was 478,30.4 percent;Fungi was 494,31.4 percent;The result of drug sensitive test indicated:the highest sensitive antibiotic:vancomycin 95.8 percent,imipenem 88.2 percent,cefepime 83.6 percent.The highest resistance antibiot- ic:clarithromycin 79.3percent,clindamycin 74.0 percent,erythromycin 73.5 percent.Conclusion:The Fungi infected rate is increas- ing,the rate of Gram positive bacteria and its resistance were high;the enzme-inhibited can reduce the resistance rate of Gram negative bacteria,not reduce the resistance rate of Gram positive bacteria.It would be strengthed the antibiotic rational use in clinic.