Challenges for measurement of myocardial perfusion and perfusion reserve by SPECT imaging

Conclusions  The present study by Storto et al¹ provides additional evidence that quantitative estimates of myocardial perfusion and perfusion reserve can be derived from SPECT myocardial perfusion images by use of equipment, tracers, and techniques that are available in most nuclear cardiology laboratories. Additional clinical studies are needed to optimize the methods used to derive the quantitative estimates of perfusion and perfusion reserve from the SPECT imaging studies and, ultimately, to determine the applicability of these measurements to the daily practice of nuclear cardiology.