口腔鳞状细胞癌中COX-2、VEGF和EGFR的表达及意义

目的 研究环氧化酶-2（COX-2）、血管内皮生长因子（VEGF）、表皮生长因子受体（EGFR）在口腔鳞状细胞癌中的表达及相互关系。方法 应用免疫组织化学SP法检测28例口腔鳞状细胞癌组织、15例正常口腔粘膜组织中COX-2、VEGF、EGFR蛋白的表达情况。结果 口腔鳞状细胞癌组织中COX-2的高表达率为60．71％，与正常口腔粘膜的表达比较有统计学意义，但与患者的性剐，年龄，肿瘤的部位及病理学分级无关（P〉0．05）。在口腔鳞状细胞癌中VEGF的阳性表达率为53．57％。EGFR高染表达率为67．86％，均与COX-2表达成正相关趋势（P〈0．05）。结论 COX-2蛋白可能在口腔鳞状细胞癌的发生发展中起作用。并且与VEGF、EGFR的表达成正相关趋势，VEGF、EGFR可能是COX-2在口腔鳞状细胞癌发生发展作用机制中的环节。

Expression of COX-2, VEGF and EGFR in oral squamous carcinomas

Objective To investigate the expression and correlativity of COX-2,VEGF and EGFR in oral squamous cell carcinomas(OSCCs).Methods The protein expression of COX-2,VEGF and EGFR in formalin-fixed and paraffin-embedded blocks of 28 OSCCs tissues and 15 normal oral tissues was analyzed by immunohistochemical method.Results Positive rate of COX-2 in OSCCs was(60.71%).There was a difference between OSCCs and normal mucosas(P<(0.05)),but no correlation was found between the positive rates of COX-2 and the age,gender of patients,locus of tumor,and pathological grade(P>(0.05)).Positive rates of VEGF and EGFR in OSCCs were(53.57%) and(67.86%),respectively.Furthermore,the protein expression of VEGF and EGFR were correlated with COX-2.Conclusion COX-2 might play a role in the carcinogenesis and progression of OSCCs.The protein expression was correlated with VEGF and EGFR,that may contribute to expression of COX-2.