| 微波法合成维拉帕米中间体-2-（3，4-二甲氧基苯基）-3-甲基苯丁腈 |
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| 引用本文： | 黄维,韩波.微波法合成维拉帕米中间体-2-（3，4-二甲氧基苯基）-3-甲基苯丁腈[J].中国现代药物应用,2008,2(23):18-19. |
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| 作者姓名： | 黄维 韩波 |
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| 作者单位： | 黄维 (成都中医药大学药学院,610000)； 韩波 (成都中医药大学药学院,610000)； |
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| 摘 要： | 目的采用微波法合成2-（3，4-二甲氧基苯基）-3-甲基苯丁腈。方法以3，4-二甲氧基苯乙腈和2-溴丙烷为原料，加入相转移催化剂苄基三乙基氯化铵，利用微波反应器进行烃化反应得到目标物。结果在电流30mA下辐射6min时，反应收率最高，可达64.5%。产物结构经液相色谱和核磁共振氢谱确认。结论此合成方法操作简便，反应时间短，明显提高反应效率。
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| 关 键 词： | 3 4-二甲氧基苯乙腈 微波法 合成 |
The synthesis of 2-(3,4-dimethoxyphenyl)-3-methylbutanenitrile by microwave technology |
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| HUANG Wei,HAN Bo.The synthesis of 2-(3,4-dimethoxyphenyl)-3-methylbutanenitrile by microwave technology[J].Chinese Journal of Modern Drug Application,2008,2(23):18-19. |
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| Authors: | HUANG Wei HAN Bo |
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| Institution: | (Pharmacy School of Chengdu University of Chinese Medicine, Chengdu 610000, China) |
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| Abstract: | Objective To synthesize 2-（3,4-dimethoxyphenyl）-3-methylbutanenitrile in application of the microwave technology. Methods The aimed compound was synthesized by using 3,4-dimethoxyphenylace-tonitrile and 2-bromopropane as the starting material with PTC （TEBA） and microwave technology. Results To synthesize it under 30 mA and 6 minutes is the optimum condition and the overall yields were 64. 5%. Chemical structure of the product was confirmed by HPLC and 1 hNMR. Conclusion The synthetic method is convenient, timesaving and efficient. |
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| Keywords: | 3 4-dimethoxyphenylacetonitrile Microwave Synthesis |
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