Outcome of Regenerative Endodontic Procedures in Nonvital Immature Permanent Teeth Using 2 Intracanal Medications: A Prospective Randomized Clinical Study |
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| Institution: | 1. Graduate Program in Dentistry, Faculty of Dentistry, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul State, Brazil;2. MSciD and PhD Post-Graduate Program in Oral Science, Faculty of Dentistry, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul State, Brazil;3. MSciD and PhD Post-Graduate Program in Chemistry, Faculty of Chemistry, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul State, Brazil;1. Center of Dental Medicine, Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zürich, Zürich, Switzerland;2. Private Practice, Gera, Germany;3. Department of Preventive Dentistry, Periodontology and Cariology, University of Göttingen, Göttingen, Germany;4. Private Practice, Kassel, Germany;1. Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China;2. Stomatological Hospital, Southern Medical University, Guangzhou, China;1. 6 Stomatological Hospital of Chongqing Medical University, Chongqing, China;2. Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing, China;3. Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, China;4. University of Southern California Herman Ostrow School of Dentistry, Los Angeles, California;6. School of Dental Medicine, Western University of Medical Sciences, Pomona, California;1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China;2. Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China;3. School of Information Engineering, Guangdong University of Technology, Guangzhou, China |
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| Abstract: | IntroductionThis randomized clinical trial aimed to assess and compare the long-term clinical and radiographic outcomes of regenerative endodontic procedures (REPs) in treating nonvital immature permanent teeth using 2 intracanal medicaments.MethodsForty-five patients yielding a total of 50 anterior and posterior nonvital immature teeth were randomly divided into 2 groups. REPs using either nonsetting calcium hydroxide (CaOH]2) (n = 25) or modified triple antibiotic paste (TAP) (n = 25) as intracanal medicaments were performed. NeoMTA Plus (Avalon Biomed Inc) was applied for coronal sealing. Cases were followed up clinically and radiographically for 36 months. The survival rate, success rate, and clinical outcome measures were analyzed. Preoperative and recall radiographs were evaluated for dimensional changes in root length, dentin thickness, apical diameter, and periapical radiolucency.ResultsAt the 36-month follow-up, the success and survival rates were 81.6% and 100%, respectively, in which 79.4% of cases showed complete resolution of periapical radiolucency with no significant difference between the nonsetting Ca(OH)2 and modified TAP groups (P > .050). The cumulative changes in root length, root dentin thickness, and apical diameter throughout the study period were observed in 47.9%, 77.1%, and 89.6% of cases, respectively, with no significant differences between groups (P ≥ .39). Intracanal calcifications were detected in 60% of cases with no significant difference between groups (P = .77).ConclusionsREPs, using either nonsetting Ca(OH)2 or modified TAP as the intracanal medicament, exhibited high success and survival rates over a follow-up period of 36 months with equally favorable clinical and radiographic outcome data. |
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| Keywords: | Immature tooth nonsetting calcium hydroxide outcome pulp regeneration regenerative endodontic procedures triple antibiotic paste |
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