Evaluation of the Effect of Common Analgesics on Pulpal Sensibility Tests: A Clinical Trial |
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| Affiliation: | 1. Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran;2. Private Practice, Tehran, Iran;3. Department of Endodontics, School of Dentistry (International Campus), Tehran University of Medical Sciences, Tehran, Iran;4. Department of Periodontics, School of Dentistry, AJA University of Medical Sciences, Tehran, Iran;5. Department of Epidemiology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran;1. Division of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;2. Division of Oral Science for Health Promotion, Department of Oral Health and Welfare, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;3. Divisions of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Tissue Regeneration & Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;4. Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan;6. Department of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan;1. Tandvårdens Kompetenscentrum, Norrbotten Public Dental Service, Luleå, Sweden;2. Norrbotten County Council, Luleå, Sweden, Department of Clinical Medicine and Public Health, Umeå University, Umeå, Sweden;3. Piteå Hospital, Norrbotten Public Dental Service, Piteå, Sweden;4. Department of Endodontics, Faculty of Odontology, Malmö University, Malmö, Sweden;5. Department of Odontology, Umeå University, Umeå, Sweden;1. Department of Endodontics, University of Iowa College of Dentistry, Iowa City, Iowa;2. Advanced Endodontics of Texas, Keller, Texas;1. US Navy Dental Corps, Fleet Forces Atlantic, Norfolk, Virginia;2. US Navy Dental Corps, Naval Medical Readiness Training Command, Naval Station Norfolk, Norfolk, Virginia;1. Department of Endodontics, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil;2. Department of Endodontics, Feira de Santana State University, Feira de Santana, Bahia, Brazil;3. Private Practice, Changwon, Republic of Korea;4. Research Director, Cybermed, Inc, Daejeon, Republic of Korea;5. Department of Endodontics, State University of Rio de Janeiro, Rio de Janeiro, Brazil;6. Department of Dentistry II, Federal University of Maranhão, São Luís, Maranhão, Brazil;7. Dental Specialty Center, Brazilian Military Police, Minas Gerais, Brazil;1. Department of Endodontics, Rey Juan Carlos University, Alcorcón, Madrid, Spain;2. Private Practice in Porto, Porto, Portugal |
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| Abstract: | IntroductionAccurate diagnosis is one of the most important steps before endodontic treatment. The aim of this study was to assess the effect of 2 commonly used analgesics namely ibuprofen and acetaminophen on the cold and electric pulp test (EPT) results in participants with symptomatic irreversible pulpitis (SIP).MethodsThis clinical trial evaluated 41 participants with pain due to SIP. The cold test and EPT were performed for teeth with SIP, and also for the corresponding tooth with healthy pulp in the contralateral quadrant. The participants then received 500 mg acetaminophen, 400 mg ibuprofen, or the placebo in the 3 groups. The cold test and EPT were repeated at 20, 40, and 60 minutes after medication intake, and the results were compared with the pretreatment values.ResultsIn the acetaminophen group, the results of cold test significantly decreased 40 (P < .05), and 60 (P < .05) minutes after analgesic intake in teeth with SIP and after 40 minutes (P < .05) in the corresponding contralateral teeth with healthy pulp. In the ibuprofen group, the cold test results significantly decreased at 20 (P < .05), 40 (P < .05), and 60 (P < .05) minutes after analgesic intake in teeth with SIP and after 40 minutes (P < .05) in the corresponding contralateral teeth with healthy pulp. The EPT results were not significantly affected by the studied analgesics at any time point (P > .05). There was no significant difference among the study groups regarding sex (P > .05).ConclusionIt appears that both acetaminophen and ibuprofen can affect the pulpal response to the cold sensibility test. However, the studied medications had no significant effect on the EPT results. Therefore, dental clinicians should be aware of the possible effects of such medications on the cold test response. |
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| Keywords: | Analgesics cold test electric pulp test pulpitis |
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