Clinical Effect Evaluation of Concentrated Growth Factor in Endodontic Microsurgery: A Cross-Sectional Study |
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| Institution: | 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Conservative Dentistry and Endodontics, West China School of Stomatology, Sichuan University, Chengdu, China;2. West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu, China;1. Division of TMD and Orofacial Pain, School of Dentistry, University of Minnesota, Minneapolis, Minnesota;2. The Center for Magnetic Resonance Research, Minneapolis, Minnesota;3. Department of Radiology, School of Dentistry, University of Minnesota, Minneapolis, Minnesota;4. Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota;6. Private Practice, The Dental Specialists, Woodbury, Minnesota;5. Division of Endodontics, School of Dentistry, University of Minnesota, Minneapolis, Minnesota;7. Private Practice, The Dental Specialists, Roseville, Minnesota;11. Minnesota Dental Research Center for Biomaterials and Biomechanics, Minneapolis, Minnesota;12. Departments of Radiology & Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota;1. Adelaide Dental School, University of Adelaide, Adelaide, South Australia, Australia;2. Sydney Dental School, University of Sydney, Sydney, New South Wales, Australia;3. University of Sharjah, College of Dental Medicine, Department of Preventive and Restorative Dentistry, Sharjah, UAE;1. 6 Stomatological Hospital of Chongqing Medical University, Chongqing, China;2. Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing, China;3. Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, China;4. University of Southern California Herman Ostrow School of Dentistry, Los Angeles, California;6. School of Dental Medicine, Western University of Medical Sciences, Pomona, California;1. Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China;2. Stomatological Hospital, Southern Medical University, Guangzhou, China;1. Graduate Program in Dentistry, Faculty of Dentistry, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul State, Brazil;2. MSciD and PhD Post-Graduate Program in Oral Science, Faculty of Dentistry, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul State, Brazil;3. MSciD and PhD Post-Graduate Program in Chemistry, Faculty of Chemistry, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul State, Brazil |
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| Abstract: | IntroductionConcentrated growth factor (CGF) is the third-generation platelet concentrate product. This study aimed to evaluate whether the use of CGF during endodontic microsurgery had a positive influence on surgical outcomes.MethodsFifty-four patients who underwent endodontic microsurgery from January 2017 to November 2021 were enrolled. They were assigned to the CGF and the control groups according to whether CGF was used during the surgery and followed up at 6, 12, and 18 months after surgery. Preoperative classification of the cases and follow-up radiographic outcomes were based on Kim’s classification and Molven’s criteria, respectively, and evaluated by 2 calibrated endodontists. The Student t test and χ2 test were used to assess the baseline of 2 groups. Rank sum test was used to determine whether CGF had an impact on the surgical outcome.ResultsThirty-one patients (41 periapical lesion sites) were included in the CGF group, and 23 patients (26 periapical lesion sites) were included in the control group. The overall success rate of endodontic microsurgery was greater than 90%. The baseline of the 2 groups had no difference (P < .05). In the CGF group, the success rate was always 100% in 3 follow-ups, whereas the success rate was 84.2%, 92.8%, and 90%, respectively, in the control group. The success rate between the CGF group and the control group was statistically significant in all 3 follow-up points (P < .05).ConclusionsThe application of CGF during endodontic microsurgery might have a positive influence on surgical outcomes, thus, its prognosis. However, higher-grade evidence is needed to demonstrate its role. |
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| Keywords: | Bone regeneration concentrated growth factor endodontic microsurgery periapical lesions |
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