烟雾吸入性急性肺损伤/急性呼吸窘迫综合征的研究进展

目前烟雾吸入性急性肺损伤（ALI）／急性呼吸窘迫综合征（ARDS）的发病机制尚未完全明确，可能与烟雾所致的氧化性损伤、肺表面活性物质变化、细胞因子改变、细胞凋亡的发生有关。与机制相应的治疗方法仍未找到，常见的临床治疗方法（如：机械通气，肺泡灌洗，药物治疗）虽然已被证明有一定疗效，但仍然无法治愈烟雾吸入性ALI／ARDS。体外二氧化碳排除及一氧化氮治疗等新方法的尝试为我们进一步研究烟雾吸入性ALI／ARDS提供了新的思路。

Advances in smoke inhalation ALI/ARDS

The pathogenesy of smoke inhalation acute lung injury/acute respiratory distress syndrome(ALI/ARDS) is not completely clear,perhaps concerned with oxidative damage,the change of pulmonary surfactant and cytokine,and apoptosis.Specific therapeutic measure is not found.Hackneyed therapeutic measures (such as: mechanical ventilation,alveolar wash,drug treatment) are demonstrated utility,but still do not cure smoke inhalation ALI/ ARDS.Some new measures such as extra-corporeal CO2 removal and NO therapy,provide new ideas to further study smoke inhalation ALI/ARDS.