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Mitochondrial IV complex and brain neurothrophic derived factor responses of mice brain cortex after downhill training |
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| Authors: | Aguiar Aderbal S Tuon Talita Pinho Cléber A Silva Luciano A Andreazza Ana C Kapczinski Flávio Quevedo João Streck Emílio L Pinho Ricardo A |
| Affiliation: | 1. Laboratório de Fisiologia e Bioquímica do Exercício, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil;2. Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, Rio Grande do Sul, Brazil;3. Bipolar Disorders Program, Centro de Pesquisas, Hospital das Clínicas de Porto Alegre, 90035-003 Porto Alegre, RS, Brazil;4. Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil;5. Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil |
| Abstract: | Twenty-four adult male CF1 mice were assigned to three groups: non-runners control, level running exercise (0 degrees incline) and downhill running exercise (16 degrees decline). Exercise groups were given running treadmill training for 5 days/week over 8 weeks. Blood lactate analysis was performed in the first and last exercise session. Mice were sacrificed 48 h after the last exercise session and their solei (citrate synthase activity) and brain cortices (BDNF levels and cytochrome c oxidase activity) were surgically removed and immediately stored at -80 degrees C for later analyses. Training significantly increased (P<0.05) citrate synthase activity when compared to untrained control. Blood lactate levels classified the exercise intensity as moderate to high. The downhill exercise training significantly reduced (P<0.05) brain cortex cytochrome c oxidase activity when compared to untrained control and level running exercise groups. BDNF levels significantly decreased (P<0.05) in both exercise groups. |
| Keywords: | BDNF Citrate synthase Cytochrome c oxidase Physical exercise |
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