| Orexin-A对氯胺酮麻醉老年大鼠苏醒的影响 |
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| 引用本文： | 王东,张旭,叶建宁,贾小兵,杨天德. Orexin-A对氯胺酮麻醉老年大鼠苏醒的影响[J]. 南方医科大学学报, 2009, 29(5): 936 |
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| 作者姓名： | 王东 张旭 叶建宁 贾小兵 杨天德 |
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| 作者单位： | 1. 第三军医大学新桥医院,麻醉科重庆,400037
2. 第三军医大学新桥医院,神经内科,重庆,400037 |
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| 基金项目： | 全军"十一五"医学科研基金 |
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| 摘 要： | 目的 观察Orexin-A对老年大鼠氯胺酮麻醉后苏醒及认知功能的影响.方法 将55只老年大鼠随机分为空白对照组10只,模型对照组、Orexin-A低剂量组、Orexin-A高剂量组各15只.以100 mg/kg氯胺酮腹腔注射建立麻醉模型.麻醉10min后,治疗组侧脑室注入Orexin-A 1、4 nmol/10μl.对照组注入等量人工脑脊液.观察各组大鼠麻醉后翻正反射持续时间;侧脑室给药前后脑电图δ波相对比的变化;Morris水迷宫检测学习记忆功能.结果 氯胺酮麻醉可使老年大鼠学习记忆能力明显下降,Orexin-A能明显缩短麻醉后大鼠翻正反射持续时间,减少δ波的相对比例,并能改善麻醉后老年大鼠的学习记忆能力,以较大剂量效果显著(P<0.05).结论 Orexin-A对氯胺酮麻醉后老年大鼠具有促醒作用,且能明显改善麻醉后大鼠认知功能.
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| 关 键 词： | 氯胺酮 苏醒 认知功能 水迷宫 |
Effect of orexin-A on recovery from ketamine anesthesia in aged rats |
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| WANG Dong,ZHANG Xu,YE Jian-ning,JIA Xiao-bing,YANG Tian-de. Effect of orexin-A on recovery from ketamine anesthesia in aged rats[J]. Journal of Southern Medical University, 2009, 29(5): 936 |
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| Authors: | WANG Dong ZHANG Xu YE Jian-ning JIA Xiao-bing YANG Tian-de |
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| Affiliation: | WANG Dong1,ZHANG Xu1,YE Jian-ning2,JIA Xiao-bing2,YANG Tian-de1 1Department of Anesthesiology,2Department of Neurology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China |
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| Abstract: | Objective To observe the effect of orexin-A on the recovery and cognitive function of aged rats after ketamine anesthesia. Methods Fifty-five aged rats were divided randomly into control group,model control group,1 nmol/L Orexin-A group,and 4 nmol/L Orexin-A group. In the latter 3 groups,the rats received an intraperitoneal injection of ketamine at 100 mg/kg,and normal saline was injected in the control group. Ten minutes after the injections,the rats received intraventricular injections of artificial cereb... |
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| Keywords: | Orexin-A |
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