| 大鼠原位肝脏隔离灌注大剂量5—Fu的病理形态学观察 |
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| 引用本文： | 邢雪,夏穗生.大鼠原位肝脏隔离灌注大剂量5—Fu的病理形态学观察[J].滨州医学院学报,1997,20(4):315-316. |
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| 作者姓名： | 邢雪 夏穗生 |
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| 作者单位： | 同济医科大学器官移植研究所 |
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| 摘 要： | 应用大鼷的位肝脏隔离灌注技术行不同剂量５－Ｆｕ肝脏灌注，观察肝脏的病理形态变化。结果：正常肝组织可耐受≤２５０ｍｇ／ｋｇ的５－Ｆｕ区域灌注，５－Ｆｕ剂量为１５０ｍｇ／ｋｇ时，肝脏超微结构为可逆性改变。此种变化与灌注液无５－Ｆｕ组、全肝血流阻断组无显著差异。结论：在允许的剂量范围内行肝 隔离灌注５－Ｆｕ并不加重肝组织的缺血再灌注损伤。
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| 关 键 词： | 5－Fu 肝肿瘤 药物疗法 |
THE PATHOLOGICAL OBSERVATIONS OF ISOLATED LIVER PERFUSION WITH LARGE DOSE 5-FU IN RATS IN VIVO |
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| Xing Xue,et al.THE PATHOLOGICAL OBSERVATIONS OF ISOLATED LIVER PERFUSION WITH LARGE DOSE 5-FU IN RATS IN VIVO[J].Journal of Binzhou Medical College,1997,20(4):315-316. |
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| Authors: | Xing Xue et al |
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| Abstract: | Isolated liver perfusion (ILP)in rats in vivo using different doses of 5 Fu was performed to observe the pathological changes of the liver.The results showed that the normal hepatic tissue could tolerate regional perfusion with no over than 250mg/kg 5 Fu.The changes of hepatic ultrastructure were reversible in ILP with 150mg/kg 5 Fu which had no significant differences compared with those of ILP without 5 Fu and total hepatic vascular exclusion.From the above it can be seen that ILP within 5 Fu of the maximal tolerance does not deteriorate ischemia reperfusion injuries of hepatic tissue. |
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| Keywords: | hepatic neoplasm chemotherapy pathology 5 Fu |
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