非小细胞肺癌组织FGFRlOP和PTEN表达及其临床意义的研究

目的:探讨FGFR1OP和PTEN蛋白在非小细胞肺癌(NSCLC)中的表达情况。方法:选取58例NSCLC手术切除标本,采用SP法进行免疫组织化学染色。结果:FGFR1OP和PTEN的阳性表达率分别为91.4%(53/58)和44.8%(26/58)。FGFR1OP的表达与肿瘤的分化程度和病理类型密切相关,在鳞癌中的表达高于腺癌,P=0.002;肿瘤的分化程度较低时(腺癌P=0.003,鳞癌P=0.001)也呈现高表达。PTEN在肺腺癌中的表达高于在鳞癌中的表达,P=0.031;肿瘤低分化(腺癌P=0.023,鳞癌P=0.015)时,表达显著降低或缺失。FGFR1OP和PTEN在肺腺癌中的表达呈负相关,r=-0.733,P=0.025。结论:FGFR1OP的高表达与PTEN的低表达或表达缺失可能参与肿瘤的生长分化和进展,并提示预后不良。

Expressions of FGFR1OP and PTEN in non-small cell lung cancer tissues and their clinical significance

OBJECTIVE:To investigate the expressions of FGFR1OP and PTEN proteins in NSCLC.METHODS:The expressions of FGFR1OP and PTEN were examined in 58 NSCLC specimens with SP method.The relationship between the expressions of those proteins and various clinicopathologic factors was evaluated.RESULTS:The positive expression rates of FGFR1OP and PTEN were 91.4%(53/58) and 44.8%(26/58),respectively.The expression of FGFR1OP was significantly assotiated with the tumor cell differentiation and different pathological types.Higher FGFR1OP was found in squamous cell carcinomas(P=0.002) and lower differentiation(P=0.003,in adenocaicinomas;P=0.001,in squamous cell carcinomas).Lower PTEN expression was correlated with poor differentiation(P=0.023,in adenocaicinomas;P=0.015,in squamous cell carcinomas) and squamous cell carcinomas(P=0.031).FGFR1OP had a nagetive correlation with PTEN in adenocaicinomas,r=-0.733,P=0.025.CONCLUSION:High FGFR1OP expression or low PTEN expression are related to the cell differentiation and the progression of NSCLC.