胰腺癌微血管壁通透性的形态学研究

目的 观察胰腺癌微血管壁的通透性相关结构,为胰腺癌药物治疗靶向性的提高提供参考.方法 选取我院切除的中分化胰腺癌10例,对肿瘤中心、边缘、瘤旁、正常/远隔胰腺4个部位进行透射电镜检测.结果 胰腺癌微血管数量和内皮窗孔数量明显少于正常胰腺组织(P<0.05),且内皮间隙和窗孔的内径并不超过正常胰腺组织.胰腺癌微血管内皮间隙内径中位数为12.8～13.2 nm,5～95百分位数为0～24.4 nm,内皮间隙存在局部扩张的现象,最宽处可以达到60.3～76.4 nm.胰腺癌微血管窗孔的内径在40.0nm左右.瘤旁组织破口较多,破口内径平均516.3 mm左右.结论 与正常胰腺组织比较,胰腺癌具有一定的微血管异质性,体现为血供较少和微血管壁通透性较低等特点.

Morphological study on permeability of pancreatic cancer microvessels

Objective To explore the permeability of walls of pancreatic cancer microvessels for improving pancreatic cancer' s tumor-targeting drug therapy. Methods Ten moderately differentiated pan-creatic cancers from patients under pancreaticoduodenectomy in our hospital were divided into 4 groups, and center of tumors, margin of tumors, tumor adjacent tissues, and normal pancreatic tissues were exam-ined under a transmission electron microscope. Results Number of microvessels and transcellular holes in endothelial cells was significantly less in pancreatic cancers than in normal pancreases ( P < 0.05), as well as inter-endothehal gaps and transcellular holes of endothelial cells were not more broad in pancreatic cancers than in normal pancreases. Median of pore size of inter-endothelial gaps of endothehal cells of pan-creatic cancer microvessels was 12.8-13.2 nm,and 5-95 percentiles of those gaps were 0-24.4 nm. The widest segments of inter-endothelial gaps could reach 60.3-76.4 nm,when dilating. Pore size of transcellu-lar holes of endothelial cells of pancreatic cancer microvessels was about 40.0 nm. There were more torn opeuniugs of microvessel walls in tumor adjacent tissues, average size of which was about 516.3 urn. Con-clusion Pancreatic cancer has some heterogenicity of microvessels, including insufficient blood vessels and low permeability of the vessels.