急性脑梗死患者颈动脉内膜中层厚度与血清VE—cadherin和脂联素水平变化 |
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引用本文: | 唐蕾蕾,黄友敏,张涛,李永涛. 急性脑梗死患者颈动脉内膜中层厚度与血清VE—cadherin和脂联素水平变化[J]. 中国临床实用医学, 2009, 3(2): 22-24 |
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作者姓名: | 唐蕾蕾 黄友敏 张涛 李永涛 |
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作者单位: | 1. 山东省济宁医学院附属滕州市中心人民医院急诊科,277500 2. 检验科,山东省济宁医学院附属滕州市中心人民医院急诊科,277500 3. 山东省济宁医学院附属滕州市中心人民医院彩超室,277500 |
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摘 要: | 目的探讨急性脑梗死患者颈总动脉平均内膜中层厚度(IMT)与血清血管内皮细胞钙黏蛋白(VE—cadherin)、脂联素(APN)的含量变化,及其在急性脑梗死发生过程中的作用和意义。方法采用高分辨率彩色超声诊断仪测量颈动脉IMT,并采用酶联免疫法测定血清VE-cadherin和APN水平,并与60例年龄和性别相当的健康体检者(对照组)进行比较。结果①急性脑梗死患者颈动脉IMT和血清VE-cadherin含量较两对照组显著升高,脂联素含量较对照组显著降低;②急性脑梗死患者颈动脉IMT和血清VE-cadherin、脂联素含量之间存在相关性。结论监测患者颈动脉IMT和血清VE-cadherin、脂联素含量变化有助于预测脑梗死的发生。
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关 键 词: | 脑梗死 血管内皮细胞钙黏蛋白 脂联素 颈动脉 内膜-中层厚度 |
Relationship between the IMT of common carotid artery and the serum level of VE-cadherin,adiponec-tion In patients with cerebral infarction |
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Affiliation: | TANG Lei-lei, HUANG You-min, ZHANG Tao, et al. (The Central People' s Hospital of Tengzhou, Shandong 277500, China) |
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Abstract: | Objective To investigate the relationship between the intima-media thickness (IMT)of common carotid artery and the serum level of VE-cadherin, adiponection (APN) in patients with cerebral infarc-tion. Methods The IMT of carotid artery were assessed by high resolution Doppler ultrasonography in 104 pa-tients with with cerebral infarction and 60 healthy controls, and the serum VE-cadherin and APN was measured using ELISA, compared with those in 60 healthy subjects. Results ①The levels of the intima-media thickness (IMT) of common carotid artery and serum VE-cadherin of patients with cerebral infarction were markedly high-er than those in the control groups, the levels adiponectin in serum of patients with cerebral infarction was markedly lower than those in the control groups. ②There was an obvious relationship between the intima-media thickness(IMT) of common carotid artery and the level of serum adiponectin and VE-cadherin. Conclusion The level of serum adiponevtin and VE-cadherin and the intima-media thickness(IMT) of common carotid artery has instructive significance in acute cerebral infarction treating and prognosis estimating. |
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Keywords: | Cerebral infarction VE-cadherin Adiponection (APN) Carotid artery Intima-media thick-ness(IMT) |
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