急性脑梗死患者颈动脉内膜中层厚度与血清VE—cadherin和脂联素水平变化

目的探讨急性脑梗死患者颈总动脉平均内膜中层厚度（IMT）与血清血管内皮细胞钙黏蛋白（VE—cadherin）、脂联素（APN）的含量变化，及其在急性脑梗死发生过程中的作用和意义。方法采用高分辨率彩色超声诊断仪测量颈动脉IMT，并采用酶联免疫法测定血清VE-cadherin和APN水平，并与60例年龄和性别相当的健康体检者（对照组）进行比较。结果①急性脑梗死患者颈动脉IMT和血清VE-cadherin含量较两对照组显著升高，脂联素含量较对照组显著降低；②急性脑梗死患者颈动脉IMT和血清VE-cadherin、脂联素含量之间存在相关性。结论监测患者颈动脉IMT和血清VE-cadherin、脂联素含量变化有助于预测脑梗死的发生。

Relationship between the IMT of common carotid artery and the serum level of VE-cadherin,adiponec-tion In patients with cerebral infarction

Objective To investigate the relationship between the intima-media thickness (IMT)of common carotid artery and the serum level of VE-cadherin, adiponection (APN) in patients with cerebral infarc-tion. Methods The IMT of carotid artery were assessed by high resolution Doppler ultrasonography in 104 pa-tients with with cerebral infarction and 60 healthy controls, and the serum VE-cadherin and APN was measured using ELISA, compared with those in 60 healthy subjects. Results ①The levels of the intima-media thickness (IMT) of common carotid artery and serum VE-cadherin of patients with cerebral infarction were markedly high-er than those in the control groups, the levels adiponectin in serum of patients with cerebral infarction was markedly lower than those in the control groups. ②There was an obvious relationship between the intima-media thickness(IMT) of common carotid artery and the level of serum adiponectin and VE-cadherin. Conclusion The level of serum adiponevtin and VE-cadherin and the intima-media thickness(IMT) of common carotid artery has instructive significance in acute cerebral infarction treating and prognosis estimating.