Selective adsorption of human CD4 T cells |
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Authors: | Matsuo Hidenori Goto Hirofumi Kambara Chiaki Fukudome Takayasu Mizota Takamitsu Onodera Hirokazu Yoshida Makoto Shibuya Noritoshi |
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Affiliation: | Division of Clinical Research, Kawatana National Hospital, Nagasaki, Japan. hidenori@kawatana.hosp.go.jp |
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Abstract: | The pathogenesis of most autoimmune diseases directly involves CD4(+) helper T cells. To remove CD4(+) T cells selectively from the circulation, we designed a new column in which an anti-CD4 monoclonal antibody was immobilized on the activated substance. Nearly 90% of CD4(+) T cells were selectively adsorbed from whole blood with a single passage through the column in vitro, resulting in depletion of the antigen-specific T cell responses. We conclude that this new column would be potentially useful for treatment of T cell-mediated autoimmune diseases. |
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Keywords: | Cytapheresis CD4 helper T cell Immunotherapy |
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