三种莨菪类药物对失血性休克大鼠不同组织氧耗量的影响

氧耗是正常组织细胞生命活动的一个基本标志，不同组织氧耗又不尽相同。失血休克后不同组织细胞氧耗量的测量，文献报道甚少，应用莨菪类药物对失血性休克大鼠不同组织氧耗量的测量亦未见文献报道，故此本文着重探讨莨菪类药物对失血性休克大鼠不同组织氧耗量的影响，为休克的防治提供依据。１　材料和方法１．１　实验动物、药品及仪器由本院动物实验室提供Ｗｉｓｔａｒ大鼠，体重２２０～２５０ｇ，雌雄不拘，分组如下：（１）正常对照组（１０只），（２）失血休克组（１０只），（３）盐酸莨菪碱组（１０只，简称６５４２），（４）溴…

Effects of Three Kinds of Hyoscyamine on Different Tissue Oxygen Consumption in Hemorrhagic Shock Rats

The tissue oxygen consumption of the heart, kidney, brain, liver, intestine of the rats, which are divided into normal contrast group, hemorrhagic shock group, Anisodamine(654 2) group, N Butyl Scopdammonium group and Anisodus tanguticus group(all n =10), were measured by using the Oximeter for biological materials. The results showed that the oxygen consumption of intestinal musoca was highest, then the kidney, brain, liver, heart, and the oxygen consumption of intestinal serosa was lowest among all. The oxygen consumption of the brain, kidney, intestinal muscle in hemorrhagic shock group was significantly higher than that of the normal contrast group, probably because the kidney, brain and intestinal muscle needed a great deal of oxygen in order to keep themselves functional in the ischemic and hypoxic states. 654 2, N Butyl Scopolammonium Bromide, and Anisodine were injected(5 mg/kg. iv.) 10 minutes before hemorrhage. The outcomes indicated that 654 2 could significantly prevent the oxygen consumption of all the above organs from increasing after hemorrhagic shock, probably because 654 2 could keep lysosome stable and improve the tolerance of Mitochondria to hypoxia. N Butyl Scopolammonium Bromide and Anisodine could keep the oxygen consumption of intestinal musoca and liver from increasing after the hemorrhagic shock, but they had no significant effect on the oxygen consumption of the heart, brain and kidney.