当归芍药散对拟血管性痴呆小鼠脑海马CGRP和SS含量的影响

目的探讨当归芍药散对血管性痴呆小鼠脑海马降钙素基因相关肽（CGRP）和生长抑素（SS）含量的影响。方法采用脑缺血再灌注的方法复制血管性痴呆小鼠模型，以脑复康为对照，通过水迷宫法分别观测术后14天各组小鼠行为学以及脑海马CGRP和SS含量的变化。结果模型小鼠学习与记忆能力下降，表现为游全程时间延长，错误次数增加，脑海马CGRP和SS含量下降；当归芍药散可使模型小鼠游全程时间缩短，错误次数减少，脑海马CGRP和SS含量升高，优于对照药物。结论当归芍药散通过调节脑海马神经肽CGRP和SS含量，可改善血管性痴呆小鼠学习与记忆能力：

The effect of DangguiShaoyao-San on CGRP and SS of Cerebral Tissue in Vascular Dementia Mice

Objective:To probe the effect of DangguiShaoyao-San on Calcitonin gene-related peptide(CGRP)and somatostatin(SS)of vascular dementia mouse.Methods To reproduct the mouse model of vascular dementia through operation of cerebral ischemia reperfusion,and contrast to Naofukang.Then,to detect the praxiological changes of each group mouse by the means of water maze and the content of CGRP and SS in hippocamp on the 14th day after operation.Results The ability of vascular dementia model mouse for learning and memory reduced,which showed extending the time for swimming the whole process,and increasing times of mistakes;the content of CGRP and SS in hippocamp reduced.DangguiShaoyao-San could make the time for swimming the whole process shorten and times of mistakes decreased,and increase the content of CGRP and SS in hippocamp,which were excellent than that of contrast medicine.Conclusion DangguiShaoyao-San could regulate the content of CGRP and SS in hippocamp and improve the learning and memory capability of model mouse.