| 羟乙基淀粉对凝血功能影响的实验研究 |
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| 引用本文： | 黄惠民 苏肇伉. 羟乙基淀粉对凝血功能影响的实验研究[J]. 上海交通大学学报(医学版), 1991, 11(4): 314-317 |
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| 作者姓名： | 黄惠民 苏肇伉 |
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| 作者单位： | 上海第二医科大学附属新华医院小儿心胸外科(黄惠民，苏肇伉，丁文祥)，上海第二医科大学附属新华医院小儿心胸外科(张伟忠) |
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| 摘 要： | 本文比较了三组失血性休克的实验犬,分别快速输给大剂量羟乙基淀粉(30ml/kg),中等剂量羟乙基淀粉(20mg/kg)和乳酸林格氏液后观察凝血指标的改变。三组血小板聚集率均有轻度异常,但较对组无显著差异:PT、KPTT和TT也均轻度延长,但组间比较亦无明显差异。因而认为羟乙基淀粉并不损伤凝血机制,作为体外循环预充液成份是安全的。
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| 关 键 词： | 羟乙基淀粉 凝血系统 休克 失血性 |
Effect of Hydroxyethyl Starch on Hemostatic Mechanism |
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| Huang Huiming,et al. Effect of Hydroxyethyl Starch on Hemostatic Mechanism[J]. Journal of Shanghai Jiaotong University:Medical Science, 1991, 11(4): 314-317 |
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| Authors: | Huang Huiming et al |
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| Affiliation: | Huang Huiming,et al Department of Thoracocardiac Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai |
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| Abstract: | 15 dogs with hemmoragic shock were randomly devided into 3 groups of 5 dogs each. 20ml/kg and 30ml/kg of blood were replaced by the same dose of hydroxyethyl strach in group A and group B, while 20ml/kg of blood in group C was replaced by Ringer's solution. 30 minutes and 4 hours after infusion, the hemostatic parameters were measured. Platelet aggregation of all three groups changed slightly but was not statistically different from control values. PT, KPTT and TT were delayed but statistical difference again did not exist between groups. We conclude that hydroxyethyl starch causes no serious damage to the hemostatic mechanism and is safe for use as a component of cardiopulnomary bypass prime. |
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| Keywords: | hydroxyethyl starch coagulation system ischemia shock |
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