98株洋葱伯克霍尔德菌临床分布及耐药性

目的分析临床分离的洋葱伯克霍尔德菌的耐药情况,为临床合理用药提供依据。方法回顾性分析2013年1月—2014年12月某院临床各科室送检标本中分离的洋葱伯克霍尔德菌,对其药敏结果进行统计分析。结果 2013年1月—2014年12月共检出洋葱伯克霍尔德菌98株,标本类型分布主要为痰(86株,占87.76%),科室分布以重症监护病房(ICU)检出最多(46株,占46.94%),洋葱伯克霍尔德菌对替卡西林/克拉维酸的耐药率最高,为73.47%,对哌拉西林/他唑巴坦和头孢哌酮/舒巴坦的耐药率均为16.33%,对米诺环素的耐药率最低,为5.10%。结论洋葱伯克霍尔德菌引起的感染耐药性高,应加强医院感染的预防与控制,及早进行病原学检查,治疗上应结合药敏结果合理用药。

Clinical distribution and antimicrobial resistance of 98 Burkholderia cepacia strains

ObjectiveTo analyze antimicrobial resistance of clinically isolated Burkholderia cepacia(B. cepacia), and provide evidence for clinical rational antimicrobial use.MethodsB. cepacia isolated from clinical specimens between January 2013 and December 2014 were analyzed retrospectively, antimicrobial susceptibility results were statistically analyzed.ResultsA total of 98 isolates of B. cepacia between January 2013 and December 2014 were isolated, the main specimen was sputum(n=86, 87.76%）, the main department distribution was intensive care unit（n=46, 46.94%），resistance rate of B. cepacia to ticarcillin / clavulanic acid was highest(73.47%), resistance rates to piperacillin / tazobactam and cefoperazone / sulbactam were both 16.33%，resistance rate to minocycline was the lowest(5.10%).ConclusionInfection caused by B. cepacia is high, prevention and control of healthcare associated infection should be strengthened, early etiological examination should be performed, antimicrobial treatment should be combined with antimicrobial susceptibility results.