冠心病患者载脂蛋白AV与脂联素关系研究

目的探讨冠心病患者血清载脂蛋白（Apo）AV与脂联素之间的关系。方法检测59例冠心病患者（冠心病组）和40例对照者（对照组）的血清总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL-C）、ApoA I、ApoB，同时采用酶联免疫吸附法测定血清ApoAV和脂联素水平。结果冠心病组血清TG显著高于对照组（1．79±1．28）mmol／L比（1．27±0．79）mmol/L]，HDL-C显著低于对照组（1．17±0．25）mmol／L比（1．29±0．26）mmol／L]，ApoAV显著低于对照组（186．71±78．20）μg／L比（250．29±110．38）μs／L]，脂联素亦显著低于对照组（3．81±0．15）mg／L比（5．33±0．37）mg／L]，P〈0．05或〈0．01。ApoAV与TG呈负相关（r=-0．208，P=0．040），与HDL-C（r=0．241，P=0．016）、脂联素（r=0．238，P=0．018）呈正相关。结论冠心病患者血清ApoAV和脂联素水平降低，TG水平增高。ApoAV与脂联素共同影响动脉粥样硬化的发展。

The correlation between serum concentrations of apolipoprotein A V and adiponectin in patients with coronary heart disease

Objective To explore the correlation between serum concentrations of apolipoprotein （APO） A V and adiponectin in patients with coronary heart disease （CHD）. Method The levels of serum total cholesterol （TC） , triglyceride （TG）, high-density lipoprotein-cholesterol （HDL-C）, low-density lipoprotein-cholesterol （LDL-C） , APOA I and APOB were examined in 99 subjects by biochemistry department. Enzyme-linked immunosorbent assay （ELISA） method was used to determine ApoA V and adiponectin. All subjects were. divided into CHD group（59 patients ） and control group（40 patients ）. Results The concentration of TG was significantly higher than that in control group （ 1.79 ± 1.28） mmol/L vs （ 1.27 ± 0.79） mmol/L ]. The concentrations of HDL-C, ApoA V and adiponectin in CHD group were significantly lower than those in control group （ 1.17± 0.25 ） mmol/L vs （ 1.29± 0.26） mmol/L, （ 186.71 ± 78.20） μg/Lvs （250.29±110.38）tLg/L, and （3.81±0.15）mg/Lvs （5.33±0.37）mg/L,P〈0.05or〈0.01]. Serum APOA V was negatively correlated with TG （r = -0.208, P = 0.040）, but positively correlated with HDL-C （r=0.241, P=0.016 ） and adiponectin （r=0.238,P=0.018）. Conclusions The patients with CHD have decreased serum levels of APOA V and adiponectin, but increased levels of TG. ApoA V and adiponectin influence the development of CHD.