糖耐量减低患者血清肝细胞生长因子水平及相关因素分析

目的观察糖耐量减低（IGT）患者血清肝细胞生长因子（HGF）水平。方法选取IGT患者（IGT组）、2型糖尿病（T2DM）患者（T2DM组）及健康对照者（NC组）各30例，分别测定血清HGF、空腹血糖（FBG）、餐后2h血糖（2hPG）、糖化血红蛋白（GHbA1C）、空腹胰岛素（FINS）、收缩压（SBP）、舒张压（DBP）等指标，并对HGF的相关因素进行分析。结果IGT组与T2DM组血清HGF水平均高于对照组分别为（413．22±102．48）、（422．76±126．77）、（120．45±25．11）ng／L]（P〈0．05），IGT组与T2DM组比较差异无统计学意义（P〉0．05）；FBG与HGF呈正相关（r=0．326，P〈0．05），多元回归分析显示，HGF与DBP具有高度相关性（r=4．730，P〈0．05）。结论血清HGF水平在IGT阶段即升高，表明存在血管内皮功能异常。

Analysis of serum hepatocyte growth factor level and related factors in impaired glucose tolerance patients

Objective To observe the level of serum hepatocyte growth factor （HGF） in patients with impaired glucose tolerance （IGT）. Methods Thirty patients with IGT （IGT group）, 30 patients with type 2 diabetes mellitus （T2DM） （T2DM group） and 30 healthy controls （control group） were recruited for this study. Such indexes a.s HGF, fasting plasma glucose （FBG）, postprandial plasma glucose （2hPG）, glycosylated hemoglobin A1c（GHbA1c）, fasting insulin（FINS）, systolic blood pressure（SBP）, diastolic blood pressure （DBP） were examined and these related factors were analyzed. Results The levels of serum HGF in IGT group and T2DM group were higher than those in control group （413.22± 102.48）,（422.76± 126.77 ）, （ 120.45± 25.11 ） ng/L, respectively ] （P 〈 0.05 ）. There was no significant different between IGT group and T2DM group （P 〉 0.05 ）. There was positive correlation between HGF and FBG （r = 0.326, P 〈 0.05 ）. Multiple regression analysis indicated significant correlation between HGF and DBP （r = 4.730, P 〈 0.05）. Conclusion Higher levels of HGF are found in IGT patients, which indicates that function of vascular endothelium is abnormal in this period.