血清肌酸激酶同工酶-MB水平与急性冠脉综合征患者预后的相关性探讨

目的探讨急性冠脉综合征（ACS）患者血清肌酸激酶同工酶-MB（CK-MB）水平与近期（发病后30、180d）心脏事件及远期（发病后360d）心脏事件的相关性。方法测定168例ACS患者的血清肌酸激酶（CK）、CK-MB，根据CK及CK-MB的水平分为四组，观察患者近期及远期心脏事件发生情况，分析CK及CK-MB与心脏事件发生的关系。结果CK-MB升高与心电图出现异常Q波、ST段改变存在相关性（P〈0．05），168例患者中共有57例患者发生心脏事件（64例次），近期心脏事件发生27例次（16．1％），远期心脏事件发生37例次（22．0％），心脏事件发生率与CK-MB水平存在相关性（P〈0．05）。结论不论CK水平如何，ACS患者的CK-MB水平升高提示患者预后较差，是ACS患者近期及远期心脏事件的独立预测因子。

The correlation of serum creatine kinaseisoenzyme-MB and the prognosis of patients with acute coronary syndrome

Objective To investigate the correlation of serum creatine kinase isoenzyme-MB（CK- MB） and recent cardiac events（30 days, 180 days） and late cardiac events （360 days） in patients with acute coronary syndrome （ACS）. Methods Serum creatine kinase （CK） and CK-MB in 168 patients with ACS were measured, and these patients were divided into four groups according to the levels of CK and CK-MB. The occurrence of cardiac events analysis of CK and CK-MB was followed up for 30, 180 and 360 days and the relationship between the occurrence of cardiac events and the levels of CK and CK-MB were studied. Results There was statistical correlation between increased CK-MB and abnormal ECG Q wave, ST segment change （P〈 0.05）, 168 patients had followed up 30, 180 and 360 days, in which cardiac events happened in 57 common patients （64 examples）, 27 examples （16.1%） happened in the recent cardiac event, and 37 examples（22.0%） happened in the late cardiac event. The cardiac event and CK-MB elevation had statistical correlation （P 〈 0.05）. Conclusion ACS patients with increased CK-MB levels prompt a poor prognosis, and could be an independent indicator of recent and late cardiac events in patients with ACS.