血浆网膜素与冠心病关系的研究

目的探讨血浆网膜素水平与冠心病的关系。方法选择2008年4-9月住院的患者88例，分为冠心病组56例（其中急性冠脉综合征28例，稳定型心绞痛28例）和非冠心病组32例。分别于入院次日空腹经肘静脉抽取静脉血，使用ELISA法测定血浆网膜素水平，并测量身高、体重、血压、总胆围醇、高密度脂蛋白胆同醇、低密度脂蛋白胆固醇、三酰甘油、高敏C反应蛋白。结果冠心病组血浆网膜素水平较非冠心病组低（33．4±6．4）μg/L比（51．8±7．7）μg/L]，差异有统计学意义（P=0．034）。多因素Logistic回归分析显示，血浆网膜素水平下降为冠心病的独立危险因素（P=0．012）．结论血浆网膜索水平下降是冠心病的独立危险因素。血浆网膜素可能在冠心病的发病机制起到一定作用，

The study on the relation between omentin and coronary artery disease

Objective To investigate the relation between omentin and coronary artery disease. Methods Eighty-eight cases were divided into 2 groups, coronary artery disease group （56 cases, including acute coronary syndrome 28 cases and stable angina 28 cases ）, and non-coronary artery disease group （32 cases）. The plasma omentin levels were assayed by ELISA, and height, weight, blood pressure, total cholesterol, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, triglyceride （TG）, high-sensitivity C-reactive protein were detected. Results The plasma omentin level in coronary after, disease group （ 33.4 ± 6.4 ） μg/L ] was lower than that in non-coronary artery disease group （ 51.8 ± 7.7 ） μg/L ] （ P = 0.034 ）. Logistic analysis showed that the decline of omentin was an independent risk factor of coronary artery disease （P = 0.012 ）. Conclusions The decline of omentin is an independent risk factor of coronary artery, disease. The plasma omentin may contribute, in part, to the pathogenesis of coronary artery disease.