Cytotoxic coumarins from Mammea harmandii |
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Authors: | Reutrakul Vichai Leewanich Pornsiri Tuchinda Patoomratana Pohmakotr Manat Jaipetch Thaworn Sophasan Samaisukh Santisuk Thawatchai |
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Institution: | Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand. scvrt@mahidol.ac.th |
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Abstract: | Two new naturally occurring coumarins, isomesuol (1) and mammearin A (2), together with nine known Mammea coumarins 3-11 were isolated from the EtOAc extract of the leaves and twigs of Mammea harmandii. Coumarins 1, 3 and 4 showed cytotoxicity against a panel of mammalian cancer cell lines. Their structures were determined by spectroscopic methods. The assignments of 13C-NMR signals of isomesuol (1), which was isolated for the first time as a natural product, have been revised. |
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