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| 四川汉族人群白细胞介素18基因多态性与鼻咽癌风险的关系 | |
| 引用本文： | 杜冰,赵娟,韦叶生. 四川汉族人群白细胞介素18基因多态性与鼻咽癌风险的关系[J]. 西部医学, 2012, 24(9): 1683-1685 |
| 作者姓名： | 杜冰 赵娟 韦叶生 |
| 作者单位： | 1. 川北医学院法医物证学教研室,四川南充,637000 2. 北川羌族自治县公安局刑侦大队,四川北川,622750 3. 右江民族医学院附属医院检验科,广西右江,533000 |
| 基金项目： | 四川省南充市科技局资助项目(编号:2008-SF006);川北医学院校基金(编号:07基-14) |
| 摘 要： | 目的研究四川汉族人群白细胞介素18基因（IL-18）-137G/C、-607C/A多态性与鼻咽癌风险的关系。方法采用病例-对照研究方法,PCR-RFLP和PCR-SSCP技术检测150例鼻咽癌患者和180例正常人群IL-18-137G/C和-607C/A基因多态性分布及与鼻咽癌风险的关系。结果病例组和对照组IL-18-137G/C基因型频率分布差异有显著性（P〈0.05）,-137G/C多态性可能与个体患鼻咽癌风险相关,等位基因C可能增加个体患鼻咽癌的风险（OR=1.783,95%CI为1.208～2.634）;-607C/A在两组中分布差异无显著性（P〉0.05）。结论 IL-18-137G/C多态性可能与鼻咽癌风险相关,-607C/A多态性与鼻咽癌易感性无关。 |
| 关 键 词： | 鼻咽肿瘤 白细胞介素18基因 遗传多态性 |
Interleukin-18 gene genetic polymorphisms and risk of nasopharyngeal carcinoma in Han population from Sichuan China |
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| DU Bing , ZHAO Juan , Wei Ye-sheng. Interleukin-18 gene genetic polymorphisms and risk of nasopharyngeal carcinoma in Han population from Sichuan China[J]. , 2012, 24(9): 1683-1685 | |
| Authors: | DU Bing ZHAO Juan Wei Ye-sheng |
| Affiliation: | 1.Department of Forensic Biology,North Sichuan Medical College,Nanchong 637000,Sichuan,China; 2.Beichuan Qiang Autonomous County Public Security Bureau,Beichuan 622750,Sichuan,China; 3.Youjiang Medical College for Nationalities,Youjiang 533000,Guangxi,China) |
| Abstract: | Objective To investigate the association of the polymorphisms of interleukin-18(IL-18)-137G/C,-607C/A polymorphisms and the risk of nasopharyngeal carcinoma in Han population from Sichuan China.Methods A case-control study was conducted involving 150 nasopharyngeal carcinoma patients and 180 healthy controls to investigate the association between the polymorphism of IL-18-137G/C,-607C/A and the risk of nasopharyngeal carcinoma.The genotypes were determined by PCR-RFLP,PCR-SSCP technique.Results The difference of IL-18-137G/C polymorphism genotypes frequency between cases and controls was significant(P<0.05),and the-137G/C polymorphism could be associated with the risk of nasopharyngeal carcinoma genesis.The allele C could increase the risk of nasopharyngeal carcinoma(OR=1.783,95%CI between 1.208 to 2.634),and the-607C/A polymorphism was not associated with the development of nasopharyngeal carcinoma.Conclusion Genetic polymorphism of IL-18-137G/C may be associated with the risk of nasopharyngeal carcinoma genesis. |
| Keywords: | Nasopharyngeal carcinoma Interleukin-18 gene Genetic polymorphism |
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