| 红景天醇提取物对老龄小鼠肝细胞过氧化脂质及其凋亡的影响 |
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| 引用本文： | 宋祥福,张静春,吴晓辉. 红景天醇提取物对老龄小鼠肝细胞过氧化脂质及其凋亡的影响[J]. 吉林大学学报(医学版), 2004, 30(5): 736-737. DOI: 吉林省中医药管理局资助课题 |
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| 作者姓名： | 宋祥福 张静春 吴晓辉 |
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| 作者单位： | 1.吉林大学公共卫生学院实验动物室，吉林 长春130021；2.吉林大学中日联谊医院检验科，吉林 长春130031 |
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| 基金项目： | 吉林省中医药管理局资助项目 |
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| 摘 要： | 目的：观察红景天醇提取物对肝细胞凋亡测定的作用。方法：肝脏和血清过氧化脂质（LPO）测定分别采用硫代巴比妥酸法及磷钨酸法，细胞周期及细胞凋亡测定采用流式细胞术。结果：红景天醇提取物显著降低小鼠肝及血清LPO含量，同时使细胞的高凋亡率显著下降。结论：红景天醇提取物具有抗肝细胞脂质过氧化及细胞凋亡的作用。
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| 关 键 词： | 过氧化脂质 细胞凋亡 |
| 文章编号： | 1671-587X(2004)05-0736-02 |
| 收稿时间： | 2002-06-26 |
| 修稿时间： | 2002-06-26 |
Effects of Rhodiola extracts on lipideperoxygen and apoptosis of hepatocytes in aged mice |
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| SONG Xiang-fu ,ZHANG Jing-chun ,WU Xiao-hui. Effects of Rhodiola extracts on lipideperoxygen and apoptosis of hepatocytes in aged mice[J]. Journal of Jilin University: Med Ed, 2004, 30(5): 736-737. DOI: 吉林省中医药管理局资助课题 |
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| Authors: | SONG Xiang-fu ZHANG Jing-chun WU Xiao-hui |
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| Affiliation: | 1. Department of Laboratory Animal, School of Pbulic Health, Jilin University, Changchun 130021，China;2. Department of Laboratory,China-Japan Union Hospital, Jilin University，Changchun 130031, China |
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| Abstract: | Objective To observe the effects of Rhodiola extracts on hepatocytes apoptosis. Methods The levels of lipideperoxygen (LPO) in liver and serum were measured by thiobabituric acid (TBA) and phosphotungstic acid,respectively. The cell cycle and apoptosis were detected by flow cytometry (FCM). Results Rhodiola extracts significantly decreased the levels of LPO in liver and serum and the higher apopototic rate of hepatocytes.Conclusion Rhodiola extracts posses the effects of against lipid peroxidation and apoptosis. |
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| Keywords: | Rhodiola lipideperoxygen apoptosis |
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